PDF(Pubmed)
Abstract：
Biofilms, structured communities of microorganisms encased in a self-produced matrix, pose significant challenges in otorhinolaryngology due to their role in chronic and recurrent infections affecting the ear, nose, and throat (ENT) region. This review provides an overview of biofilms, emphasizing their formation, pathogenesis, diagnosis, and treatment strategies in otorhinolaryngological disorders. Biofilms are pivotal in chronic rhinosinusitis (CRS), otitis media, laryngopharyngeal reflux (LPR), and tonsillitis, contributing to treatment resistance and disease recurrence. Current diagnostic techniques, including imaging modalities, microbiological cultures, and molecular techniques, are discussed, alongside emerging technologies. Treatment strategies, ranging from conventional antibiotics to alternative therapies, such as biofilm disruptors, phage therapy, and immunomodulation, are evaluated in terms of their efficacy and potential clinical applications. The review underscores the significance of understanding biofilms in otorhinolaryngology and highlights the need for tailored approaches to diagnosis and management to improve patient outcomes.
摘要：
生物膜,被包裹在自产基质中的结构化微生物群落，由于它们在影响耳朵的慢性和复发性感染中的作用，在耳鼻咽喉科中构成重大挑战，鼻子,和咽喉（ENT）区域。这篇综述概述了生物膜，强调他们的形成，发病机制，诊断,耳鼻喉科疾病的治疗策略。生物膜在慢性鼻窦炎（CRS）中至关重要，中耳炎,咽喉反流(LPR),和扁桃体炎,有助于治疗抵抗和疾病复发。当前的诊断技术，包括成像模式，微生物培养，和分子技术，讨论，新兴技术。治疗策略,从常规抗生素到替代疗法，比如生物膜干扰物，噬菌体疗法,和免疫调节，根据其疗效和潜在的临床应用进行评估。该综述强调了了解耳鼻咽喉科生物膜的重要性，并强调了需要量身定制的诊断和管理方法以改善患者预后。
