PDF(Pubmed)
Abstract：
UNASSIGNED: Despite recommendations for COVID-19 vaccination in pregnant people, the effect of vaccination on neonatal outcomes remains unknown. We sought to determine the association between COVID-19 vaccination status in pregnancy and presence of neonatally diagnosed congenital anomalies.
UNASSIGNED: A comprehensive vaccine registry was combined with a delivery database to create a cohort including all patients aged 16-55 years with a delivery event between December 10, 2020 and December 31, 2021 at a hospital within the Mayo Clinic Health System. Pregnancy and neonatal outcomes were analyzed in relation to vaccination status and timing, including a composite measure of congenital anomalies diagnosed in neonatal life. Comparisons between cohorts were conducted using chi-square test for categorical and Kruskal-Wallis test for continuous variables. A multivariable logistic regression was modeled to assess the association with congenital anomalies.
UNASSIGNED: 5,096 mother-infant pairs were analyzed. A total of 1,158 were vaccinated, with 314 vaccinated in the first trimester. COVID-19 vaccination status, including vaccination during the first trimester of pregnancy, was not associated with an increased risk of composite congenital anomalies. When further examining congenital anomalies by organ system, we did demonstrate a significant difference in eye, ear, face, neck anomalies between vaccinated and not vaccinated groups (Table 3, Not vaccinated = 2.3%, Vaccinated = 3.3%, p-value 0.04) however we did not demonstrate this difference between the 1st trimester and not vaccinated groups (Not vaccinated = 2.3%, 1st Trimester = 2.5%, p-value 0.77). No differences were found between not vaccinated, vaccinated, or 1st trimester vaccinated groups for any other organ systems. There were no differences in birthweight by gestational age, APGAR scores, incidence of NICU admission, or living status of the neonate by vaccination status.
UNASSIGNED: We add additional information regarding the safety of COVID-19 vaccination status and timing as it pertains to neonatal composite congenital anomalies, with no association demonstrated. Our findings agree with prior literature that COVID-19 vaccination is not associated with adverse pregnancy outcomes or small for gestational age neonates. Further research is needed to elucidate the association between COVID-19 vaccination and eye, ear, face, neck, anomalies.
UNASSIGNED: A comprehensive vaccine registry was combined with a delivery database to create a cohort including all patients aged 16-55 years with a delivery event between December 10, 2020 and December 31, 2021 at a hospital within the Mayo Clinic Health System. Pregnancy and neonatal outcomes were analyzed in relation to vaccination status and timing, including a composite measure of congenital anomalies diagnosed in neonatal life. Comparisons between cohorts were conducted using chi-square test for categorical and Kruskal-Wallis test for continuous variables. A multivariable logistic regression was modeled to assess the association with congenital anomalies.
UNASSIGNED: 5,096 mother-infant pairs were analyzed. A total of 1,158 were vaccinated, with 314 vaccinated in the first trimester. COVID-19 vaccination status, including vaccination during the first trimester of pregnancy, was not associated with an increased risk of composite congenital anomalies. When further examining congenital anomalies by organ system, we did demonstrate a significant difference in eye, ear, face, neck anomalies between vaccinated and not vaccinated groups (Table 3, Not vaccinated = 2.3%, Vaccinated = 3.3%, p-value 0.04) however we did not demonstrate this difference between the 1st trimester and not vaccinated groups (Not vaccinated = 2.3%, 1st Trimester = 2.5%, p-value 0.77). No differences were found between not vaccinated, vaccinated, or 1st trimester vaccinated groups for any other organ systems. There were no differences in birthweight by gestational age, APGAR scores, incidence of NICU admission, or living status of the neonate by vaccination status.
UNASSIGNED: We add additional information regarding the safety of COVID-19 vaccination status and timing as it pertains to neonatal composite congenital anomalies, with no association demonstrated. Our findings agree with prior literature that COVID-19 vaccination is not associated with adverse pregnancy outcomes or small for gestational age neonates. Further research is needed to elucidate the association between COVID-19 vaccination and eye, ear, face, neck, anomalies.
摘要：
■尽管建议在孕妇中接种COVID-19疫苗，疫苗接种对新生儿结局的影响尚不清楚.我们试图确定妊娠COVID-19疫苗接种状态与新生儿诊断的先天性异常之间的关系。
将全面的疫苗注册与交付数据库相结合，以创建一个队列，其中包括在2020年12月10日至2021年12月31日期间在梅奥诊所卫生系统内的一家医院发生交付事件的所有16-55岁患者。分析妊娠和新生儿结局与疫苗接种状态和时机的关系。包括在新生儿生活中诊断出的先天性异常的综合测量。队列之间的比较使用卡方检验进行分类，并使用Kruskal-Wallis检验进行连续变量。建立多变量逻辑回归模型以评估与先天性异常的关联。
■分析了5,096对母婴。共接种了1,158人,在孕早期接种314疫苗。COVID-19疫苗接种状况，包括在怀孕的头三个月接种疫苗，与复合先天性异常的风险增加无关。当进一步检查器官系统的先天性异常时，我们确实证明了眼睛的显著差异，耳朵,脸,接种疫苗组和未接种疫苗组之间的颈部异常(表3，未接种疫苗=2.3%，接种疫苗=3.3%，p值0.04），但是我们没有证明孕早期和未接种组之间的这种差异（未接种=2.3％，孕早期=2.5%，p值0.77)。未接种疫苗之间没有发现差异，已接种疫苗或任何其他器官系统的妊娠早期疫苗接种组。不同胎龄的出生体重没有差异，APGAR分数,NICU入院的发生率，或通过疫苗接种状态新生儿的生活状态。
我们增加了关于COVID-19疫苗接种状态和时机的安全性的更多信息，因为它与新生儿复合先天性异常有关，没有关联证明。我们的发现与先前的文献一致，即COVID-19疫苗接种与不良妊娠结局或小于胎龄新生儿无关。需要进一步的研究来阐明COVID-19疫苗接种与眼睛之间的关系，耳朵,脸,脖子,异常。
将全面的疫苗注册与交付数据库相结合，以创建一个队列，其中包括在2020年12月10日至2021年12月31日期间在梅奥诊所卫生系统内的一家医院发生交付事件的所有16-55岁患者。分析妊娠和新生儿结局与疫苗接种状态和时机的关系。包括在新生儿生活中诊断出的先天性异常的综合测量。队列之间的比较使用卡方检验进行分类，并使用Kruskal-Wallis检验进行连续变量。建立多变量逻辑回归模型以评估与先天性异常的关联。
■分析了5,096对母婴。共接种了1,158人,在孕早期接种314疫苗。COVID-19疫苗接种状况，包括在怀孕的头三个月接种疫苗，与复合先天性异常的风险增加无关。当进一步检查器官系统的先天性异常时，我们确实证明了眼睛的显著差异，耳朵,脸,接种疫苗组和未接种疫苗组之间的颈部异常(表3，未接种疫苗=2.3%，接种疫苗=3.3%，p值0.04），但是我们没有证明孕早期和未接种组之间的这种差异（未接种=2.3％，孕早期=2.5%，p值0.77)。未接种疫苗之间没有发现差异，已接种疫苗或任何其他器官系统的妊娠早期疫苗接种组。不同胎龄的出生体重没有差异，APGAR分数,NICU入院的发生率，或通过疫苗接种状态新生儿的生活状态。
我们增加了关于COVID-19疫苗接种状态和时机的安全性的更多信息，因为它与新生儿复合先天性异常有关，没有关联证明。我们的发现与先前的文献一致，即COVID-19疫苗接种与不良妊娠结局或小于胎龄新生儿无关。需要进一步的研究来阐明COVID-19疫苗接种与眼睛之间的关系，耳朵,脸,脖子,异常。
