PDF(Pubmed)
Abstract：
UNASSIGNED: As a result of the physiological decline in renal function that comes with age and the common failure to recognise renal insufficiency, older adults aged 65 and above are at increased risk of receiving medications that are inappropriate for their level of renal function which in turn lead to increased risk of adverse effects. Little is known about how many older adults receive medications that are inappropriate for their level of renal function. This study aimed to determine the prevalence of renally inappropriate medications in elderly adults by reviewing patient files and evaluating the appropriateness of medication doses relative to renal function in patients aged ≥ 65 years at inpatient healthcare departments.
UNASSIGNED: A retrospective cross-sectional study of patients aged ≥ 65 years was conducted, covering cases from 2015 to 2021. Patient\'s medical records were reviewed, their renal function and medications lists were evaluated, determined whether they had been prescribed at least one renally inappropriate medication based on drug-dosing recommendations for different degrees of renal function.
UNASSIGNED: A total of 317 elderly inpatients were included, 10% of whom had received inappropriate doses relative to their renal function. Glomerular filtration rate was associated with inappropriate dosing in this study. Of the patients CKD stage 5, 36.8% had at least one drug administered at an inappropriate dose, while this figure was 6.5% among the patients at CKD stage 1; this difference was statistically significant (p = 0.001).
UNASSIGNED: A notable portion of older adults may be at risk of adverse effects due to inappropriate medication dosing related to their renal function. Further studies with large samples, drug use analyses based on comprehensive geriatric references and a prioritisation of actual outcomes over potential outcomes are needed to further determine elderly adults\' exposure to inappropriate drugs.
UNASSIGNED: A retrospective cross-sectional study of patients aged ≥ 65 years was conducted, covering cases from 2015 to 2021. Patient\'s medical records were reviewed, their renal function and medications lists were evaluated, determined whether they had been prescribed at least one renally inappropriate medication based on drug-dosing recommendations for different degrees of renal function.
UNASSIGNED: A total of 317 elderly inpatients were included, 10% of whom had received inappropriate doses relative to their renal function. Glomerular filtration rate was associated with inappropriate dosing in this study. Of the patients CKD stage 5, 36.8% had at least one drug administered at an inappropriate dose, while this figure was 6.5% among the patients at CKD stage 1; this difference was statistically significant (p = 0.001).
UNASSIGNED: A notable portion of older adults may be at risk of adverse effects due to inappropriate medication dosing related to their renal function. Further studies with large samples, drug use analyses based on comprehensive geriatric references and a prioritisation of actual outcomes over potential outcomes are needed to further determine elderly adults\' exposure to inappropriate drugs.
摘要：
■由于肾功能随着年龄的增长而出现的生理衰退以及对肾功能不全的普遍认识不足，65岁及以上的老年人接受不适合其肾功能水平的药物治疗的风险增加,这反过来导致不良反应的风险增加.很少有人知道有多少老年人接受不适合其肾功能水平的药物。本研究旨在通过查看患者档案并评估住院医疗部门≥65岁患者的药物剂量相对于肾功能的适当性，来确定老年人肾脏不适当药物的患病率。
■对年龄≥65岁的患者进行了回顾性横断面研究，涵盖2015年至2021年的案件。患者的医疗记录进行了审查，他们的肾功能和药物清单进行了评估，根据针对不同程度肾功能的药物剂量建议,确定他们是否服用了至少一种不适合肾脏的药物.
■总共包括317名老年住院患者，其中10％的人接受了与肾功能有关的不适当剂量。在这项研究中，肾小球滤过率与不适当的剂量有关。在CKD5期患者中，36.8%的患者至少有一种药物以不适当的剂量给药，而在CKD1期患者中，这一数字为6.5%；这一差异具有统计学意义(p=0.001)。
■由于与肾功能相关的不适当的药物剂量，相当一部分老年人可能面临不良反应的风险。大样本的进一步研究，为了进一步确定老年人接触不适当药物的情况,需要根据综合的老年学参考进行药物使用分析,并将实际结果优先于潜在结果.
■对年龄≥65岁的患者进行了回顾性横断面研究，涵盖2015年至2021年的案件。患者的医疗记录进行了审查，他们的肾功能和药物清单进行了评估，根据针对不同程度肾功能的药物剂量建议,确定他们是否服用了至少一种不适合肾脏的药物.
■总共包括317名老年住院患者，其中10％的人接受了与肾功能有关的不适当剂量。在这项研究中，肾小球滤过率与不适当的剂量有关。在CKD5期患者中，36.8%的患者至少有一种药物以不适当的剂量给药，而在CKD1期患者中，这一数字为6.5%；这一差异具有统计学意义(p=0.001)。
■由于与肾功能相关的不适当的药物剂量，相当一部分老年人可能面临不良反应的风险。大样本的进一步研究，为了进一步确定老年人接触不适当药物的情况,需要根据综合的老年学参考进行药物使用分析,并将实际结果优先于潜在结果.
