PDF(Pubmed)
Abstract：
UNASSIGNED: Myosteatosis is a well-established predictor of poor prognosis in many types of cancer, and a decreased Creatinine/Cystatin C ratio (CCR) is a known indicator of unfavorable outcomes in patients with metabolic disorders and cancer. Despite this knowledge, the significance of concurrent CCR and myosteatosis in predicting the prognosis of patients with cholangiocarcinoma (CCA) who undergo radical surgery remains uncertain.
UNASSIGNED: Data from 757 patients with cholangiocarcinoma who underwent the first radical resection in the Affiliated Hospital of Qingdao University from January 2017 to March 2022 were collected. According to the inclusion and exclusion criteria, 149 patients were finally included in the retrospective study cohort. Various clinicopathological, serological, and radiological data were collected at admission. Myosteatosis was evaluated using sliceOmatic software on computed tomography (CT) images. The study used receiver operating characteristic (ROC) curve analysis to determine the critical value of CCR, which predicts overall survival (OS) based on the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were employed to identify the risk factors associated with OS and RFS confidently.
UNASSIGNED: The group identified as the myosteatosis cohort consisted of 79 patients with an average age of 64.3 ± 7.8 years. The ROC curve analysis revealed an optimal critical CCR value of 10.834. A low CCR ≤ 10.834 and myosteatosis were found to be associated with poor OS and RFS outcomes (P = 0.022; P = 0.017; P = 0.038; P = 0.030 respectively). Moreover, patients with myosteatosis and a CCR ≤ 10.834 had the worst OS and RFS outcomes (P = 0.035; P = 0.027).
UNASSIGNED: After radical excision in CCA patients, the presence of myosteatosis and CCR had a negative correlation with prognosis. A more accurate prediction of OS and RFS was possible by combining CCR and myosteatosis, compared to CCR alone.
UNASSIGNED: Data from 757 patients with cholangiocarcinoma who underwent the first radical resection in the Affiliated Hospital of Qingdao University from January 2017 to March 2022 were collected. According to the inclusion and exclusion criteria, 149 patients were finally included in the retrospective study cohort. Various clinicopathological, serological, and radiological data were collected at admission. Myosteatosis was evaluated using sliceOmatic software on computed tomography (CT) images. The study used receiver operating characteristic (ROC) curve analysis to determine the critical value of CCR, which predicts overall survival (OS) based on the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were employed to identify the risk factors associated with OS and RFS confidently.
UNASSIGNED: The group identified as the myosteatosis cohort consisted of 79 patients with an average age of 64.3 ± 7.8 years. The ROC curve analysis revealed an optimal critical CCR value of 10.834. A low CCR ≤ 10.834 and myosteatosis were found to be associated with poor OS and RFS outcomes (P = 0.022; P = 0.017; P = 0.038; P = 0.030 respectively). Moreover, patients with myosteatosis and a CCR ≤ 10.834 had the worst OS and RFS outcomes (P = 0.035; P = 0.027).
UNASSIGNED: After radical excision in CCA patients, the presence of myosteatosis and CCR had a negative correlation with prognosis. A more accurate prediction of OS and RFS was possible by combining CCR and myosteatosis, compared to CCR alone.
摘要：
■肌萎缩症是许多类型癌症预后不良的公认预测指标，肌酐/胱抑素C比值(CCR)降低是代谢紊乱和癌症患者不良结局的已知指标.尽管有这些知识,CCR和肌萎缩在预测接受根治性手术的胆管癌(CCA)患者预后中的意义仍不确定.
■收集2017年1月至2022年3月在青岛大学附属医院接受首次根治性切除术的757例胆管癌患者的数据。根据纳入和排除标准，149例患者最终纳入回顾性研究队列。各种临床病理，血清学,入院时收集放射学数据。使用sliceOmatic软件在计算机断层扫描（CT）图像上评估了肌肉骨化。该研究使用受试者工作特性（ROC）曲线分析来确定CCR的临界值，基于Kaplan-Meier方法预测总生存期(OS)。采用单变量和多变量Cox回归分析来确定与OS和RFS相关的危险因素。
■确定为肌骨形成队列的组由79名患者组成，平均年龄为64.3±7.8岁。ROC曲线分析显示最佳临界CCR值为10.834。发现低CCR≤10.834和肌骨形成与不良OS和RFS结局相关（分别为P=0.022;P=0.017;P=0.038;P=0.030）。此外，骨化病且CCR≤10.834的患者的OS和RFS结局最差(P=0.035;P=0.027).
■CCA患者根治性切除术后，肌萎缩和CCR的存在与预后呈负相关.通过结合CCR和肌肉骨化可以更准确地预测OS和RFS，与单独的CCR相比。
■收集2017年1月至2022年3月在青岛大学附属医院接受首次根治性切除术的757例胆管癌患者的数据。根据纳入和排除标准，149例患者最终纳入回顾性研究队列。各种临床病理，血清学,入院时收集放射学数据。使用sliceOmatic软件在计算机断层扫描（CT）图像上评估了肌肉骨化。该研究使用受试者工作特性（ROC）曲线分析来确定CCR的临界值，基于Kaplan-Meier方法预测总生存期(OS)。采用单变量和多变量Cox回归分析来确定与OS和RFS相关的危险因素。
■确定为肌骨形成队列的组由79名患者组成，平均年龄为64.3±7.8岁。ROC曲线分析显示最佳临界CCR值为10.834。发现低CCR≤10.834和肌骨形成与不良OS和RFS结局相关（分别为P=0.022;P=0.017;P=0.038;P=0.030）。此外，骨化病且CCR≤10.834的患者的OS和RFS结局最差(P=0.035;P=0.027).
■CCA患者根治性切除术后，肌萎缩和CCR的存在与预后呈负相关.通过结合CCR和肌肉骨化可以更准确地预测OS和RFS，与单独的CCR相比。
