PDF(Pubmed)
Abstract：
UNASSIGNED: Early supplementation and subsequent discontinuation of cow\'s milk formula (CMF) may increase the risk of cow\'s milk allergy in breast-fed infants, but little is known about the relationship between continuous CMF ingestion and cow\'s milk protein-specific immunoglobulin production.
UNASSIGNED: This study aimed to clarify the aforesaid relationship in cow\'s milk-sensitized infants.
UNASSIGNED: Using data from a randomized controlled trial of a Japanese birth cohort, we performed a subgroup analysis of participants who had ingested CMF in the first 3 days of life and exhibited a positive skin prick test response to cow\'s milk at age 6 months. We compared the differences in median titers of cow\'s milk-specific IgE, casein-specific IgE, and casein-specific IgG4 levels between participants who continued daily or intermittent CMF ingestion up to age 6 months (the \"continuous group\") and participants who discontinued CMF ingestion before age 6 months (the \"discontinued group\").
UNASSIGNED: From among 462 trial participants, 49 (10.6%) were included in this study (21 in the continuous group and 29 in the discontinued group). The median titer of cow\'s milk-specific IgE was 0.17 kUA/L (interquartile range [IQR] = <0.10 to 0.57) in the continuous group and 0.66 kUA/L (IQR = 0.49-1.18) in the discontinued group (P = .0008). The median titer of casein-specific IgE was <0.10 kUA/L (IQR = <0.10 to 0.15) in the continuous group and <0.10 kUA/L (IQR = <0.10 to 0.37) in the discontinued group (P = .51). The median titer of casein-specific IgG4 was 2.58 mgA/L (IQR = 0.77-6.73) in the continuous group and 0.09 mgA/L (IQR = 0.07-0.13) in the discontinued group (P < .0001).
UNASSIGNED: Continuous CMF ingestion may promote casein-specific IgG4 production in cow\'s milk-sensitized infants.
UNASSIGNED: This study aimed to clarify the aforesaid relationship in cow\'s milk-sensitized infants.
UNASSIGNED: Using data from a randomized controlled trial of a Japanese birth cohort, we performed a subgroup analysis of participants who had ingested CMF in the first 3 days of life and exhibited a positive skin prick test response to cow\'s milk at age 6 months. We compared the differences in median titers of cow\'s milk-specific IgE, casein-specific IgE, and casein-specific IgG4 levels between participants who continued daily or intermittent CMF ingestion up to age 6 months (the \"continuous group\") and participants who discontinued CMF ingestion before age 6 months (the \"discontinued group\").
UNASSIGNED: From among 462 trial participants, 49 (10.6%) were included in this study (21 in the continuous group and 29 in the discontinued group). The median titer of cow\'s milk-specific IgE was 0.17 kUA/L (interquartile range [IQR] = <0.10 to 0.57) in the continuous group and 0.66 kUA/L (IQR = 0.49-1.18) in the discontinued group (P = .0008). The median titer of casein-specific IgE was <0.10 kUA/L (IQR = <0.10 to 0.15) in the continuous group and <0.10 kUA/L (IQR = <0.10 to 0.37) in the discontinued group (P = .51). The median titer of casein-specific IgG4 was 2.58 mgA/L (IQR = 0.77-6.73) in the continuous group and 0.09 mgA/L (IQR = 0.07-0.13) in the discontinued group (P < .0001).
UNASSIGNED: Continuous CMF ingestion may promote casein-specific IgG4 production in cow\'s milk-sensitized infants.
摘要：
■早期补充和随后停止牛奶配方（CMF）可能会增加母乳喂养婴儿牛奶过敏的风险，但对连续摄入CMF与牛乳蛋白特异性免疫球蛋白产生之间的关系知之甚少。
■本研究旨在阐明上述关系在牛乳致敏婴儿中的作用。
■使用来自日本出生队列的随机对照试验的数据，我们对出生后前3天摄入CMF的参与者进行了亚组分析,这些参与者在6月龄时对牛奶的皮肤点刺试验反应呈阳性.我们比较了牛奶特异性IgE的中位数滴度的差异，酪蛋白特异性IgE,持续每日或间歇性CMF摄入至6月龄的参与者(“连续组”)和在6月龄前停止CMF摄入的参与者(“停止组”)之间的酪蛋白特异性IgG4水平。
■在462名试验参与者中，49（10.6%）纳入本研究（21在连续组中，29在停止组）。连续组牛奶特异性IgE的滴度中位数为0.17kUA/L（四分位距[IQR]=<0.10至0.57），停药组为0.66kUA/L（IQR=0.49-1.18）（P=.0008）。连续组酪蛋白特异性IgE滴度中位数<0.10kUA/L(IQR=<0.10~0.15),停药组<0.10kUA/L(IQR=<0.10~0.37)(P=.51)。连续组的酪蛋白特异性IgG4滴度中位数为2.58mgA/L（IQR=0.77-6.73），停药组为0.09mgA/L（IQR=0.07-0.13）（P<0.0001）。
■连续摄入CMF可能会促进牛奶致敏婴儿中酪蛋白特异性IgG4的产生。
■本研究旨在阐明上述关系在牛乳致敏婴儿中的作用。
■使用来自日本出生队列的随机对照试验的数据，我们对出生后前3天摄入CMF的参与者进行了亚组分析,这些参与者在6月龄时对牛奶的皮肤点刺试验反应呈阳性.我们比较了牛奶特异性IgE的中位数滴度的差异，酪蛋白特异性IgE,持续每日或间歇性CMF摄入至6月龄的参与者(“连续组”)和在6月龄前停止CMF摄入的参与者(“停止组”)之间的酪蛋白特异性IgG4水平。
■在462名试验参与者中，49（10.6%）纳入本研究（21在连续组中，29在停止组）。连续组牛奶特异性IgE的滴度中位数为0.17kUA/L（四分位距[IQR]=<0.10至0.57），停药组为0.66kUA/L（IQR=0.49-1.18）（P=.0008）。连续组酪蛋白特异性IgE滴度中位数<0.10kUA/L(IQR=<0.10~0.15),停药组<0.10kUA/L(IQR=<0.10~0.37)(P=.51)。连续组的酪蛋白特异性IgG4滴度中位数为2.58mgA/L（IQR=0.77-6.73），停药组为0.09mgA/L（IQR=0.07-0.13）（P<0.0001）。
■连续摄入CMF可能会促进牛奶致敏婴儿中酪蛋白特异性IgG4的产生。
