PDF(Pubmed)
Abstract：
Nuclear and chemical weapons of mass destruction share both a tragic and beneficial legacy in mankind\'s history and health. The horrific health effects of ionizing radiation and mustard gas exposures unleashed during disasters, wars, and conflicts have been harnessed to treat human health maladies. Both agents of destruction have been transformed into therapies to treat a wide range of cancers. The discovery of therapeutic uses of radiation and sulfur mustard was largely due to observations by clinicians treating victims of radiation and sulfur mustard gas exposures. Clinicians identified vulnerability of leukocytes to these agents and repurposed their use in the treatment of leukemias and lymphomas. Given the overlap in therapeutic modalities, it goes to reason that there may be common mechanisms to target as protective strategies against their damaging effects. This commentary will highlight oxidative stress as a common mechanism shared by both radiation and sulfur mustard gas exposures and discuss potential therapies targeting oxidative stress as medical countermeasures against the devastating lung diseases wrought by these agents.
摘要：
核武器和大规模毁灭性化学武器在人类历史和健康中都有着悲惨而有益的遗产。在灾难期间释放的电离辐射和芥子气暴露对健康的可怕影响，战争,和冲突已经被用来治疗人类健康疾病。两种破坏剂都已转化为治疗多种癌症的疗法。辐射和硫芥子气的治疗用途的发现主要是由于临床医生对辐射和硫芥子气暴露的受害者进行的观察。临床医生确定了白细胞对这些药物的脆弱性，并将其用于治疗白血病和淋巴瘤。鉴于治疗方式的重叠，有理由认为，可能有共同的机制作为针对其破坏性影响的保护策略。这篇评论将强调氧化应激作为辐射和硫芥子气暴露的共同机制，并讨论针对氧化应激的潜在疗法，作为针对这些药物造成的破坏性肺部疾病的医学对策。
