PDF(Pubmed)
Abstract：
Myosteatosis, or the infiltration of fatty deposits into skeletal muscle, occurs with advancing age and contributes to the health and functional decline of older adults. Myosteatosis and its inflammatory milieu play a larger role in adipose tissue dysfunction, muscle tissue dysfunction, and increased passive muscle stiffness. Combined with the age-related decline of sex hormones and development of anabolic resistance, myosteatosis also contributes to insulin resistance, impaired muscle mechanics, loss of force production from the muscle, and increased risk of chronic disease. Due to its highly inflammatory secretome and the downstream negative effects on muscle metabolism and mechanics, myosteatosis has become an area of interest for aging researchers and clinicians. Thus far, myosteatosis treatments have had limited success, as many lack the potency to completely rescue the metabolic and physical consequences of myosteatosis. Future research is encouraged for the development of reliable assessment methods for myosteatosis, as well as the continued exploration of pharmacological, nutritional, and exercise-related interventions that may lead to the success in attenuating myosteatosis and its clinical consequences within the aging population.
摘要：
肌肉骨化,或者脂肪沉积物渗入骨骼肌，随着年龄的增长而发生，并导致老年人的健康和功能下降。肌肉骨化及其炎症环境在脂肪组织功能障碍中起着更大的作用，肌肉组织功能障碍，和增加被动肌肉僵硬。结合与年龄相关的性激素下降和合成代谢抗性的发展，肌肉骨化也会导致胰岛素抵抗，肌肉力学受损，肌肉产生力的损失，和慢性疾病的风险增加。由于其高度炎性的分泌组和下游对肌肉代谢和力学的负面影响，肌肉骨化已成为衰老研究人员和临床医生关注的领域。到目前为止,肌肉骨化治疗取得了有限的成功，因为许多人缺乏完全挽救肌萎缩的代谢和物理后果的效力。鼓励未来的研究，以开发可靠的评估方法，以及药理学的持续探索，营养,以及与运动相关的干预措施，可能导致在老年人群中成功减轻肌萎缩及其临床后果。
