Abstract：
OBJECTIVE: Predictive value of systemic immune-inflammation index (SII) has been shown in clinical outcomes and complexity of coronary artery disease, acute coronary syndrome, and heart failure. We sight to evaluate value of SII in patients with lower extremity arterial disease (LEAD).
METHODS: A total of 271 patients diagnosed with LEAD were included to our study. Blood samples of the patients were collected and analyzed for biochemical variables and complete blood count parameters. SII value of each patient was calculated. The complexity of atherosclerotic disease was classified according to Trans-Atlantic Inter-Society Consensus (TASC II) classification.
RESULTS: Patients with TASC C-D were older than patients in TASC A-B group (63.06 ± 9.24 years and 60.85 ± 8.75 years, respectively). Other co-morbidities were comparable in both groups. Hemoglobin level and lymphocyte count were significantly lower, neutrophil, platelet counts, and SII values were significantly higher in patients with TASC C-D disease compared to that of patients with TASC A-B disease. SII showed significant correlation with the severity of LEAD (r = 0.363, p < .001). SII value of 664.24 predicted TASC C-D disease with a sensitivity and specificity of 60.8% and 73.3%, respectively. Results of multivariate logistic regression analysis showed that SII had higher odds ratio compared to platelet, neutrophil, and lymphocyte counts.
CONCLUSIONS: Higher SII may indicate probability of more complex LEAD. This relationship seems plausible in terms of similar pathophysiology of coronary artery disease and peripheral artery disease.
METHODS: A total of 271 patients diagnosed with LEAD were included to our study. Blood samples of the patients were collected and analyzed for biochemical variables and complete blood count parameters. SII value of each patient was calculated. The complexity of atherosclerotic disease was classified according to Trans-Atlantic Inter-Society Consensus (TASC II) classification.
RESULTS: Patients with TASC C-D were older than patients in TASC A-B group (63.06 ± 9.24 years and 60.85 ± 8.75 years, respectively). Other co-morbidities were comparable in both groups. Hemoglobin level and lymphocyte count were significantly lower, neutrophil, platelet counts, and SII values were significantly higher in patients with TASC C-D disease compared to that of patients with TASC A-B disease. SII showed significant correlation with the severity of LEAD (r = 0.363, p < .001). SII value of 664.24 predicted TASC C-D disease with a sensitivity and specificity of 60.8% and 73.3%, respectively. Results of multivariate logistic regression analysis showed that SII had higher odds ratio compared to platelet, neutrophil, and lymphocyte counts.
CONCLUSIONS: Higher SII may indicate probability of more complex LEAD. This relationship seems plausible in terms of similar pathophysiology of coronary artery disease and peripheral artery disease.
摘要：
目的：全身免疫-炎症指数（SII）在冠心病的临床结局和复杂性中的预测价值，急性冠脉综合征,和心力衰竭。我们瞻望评价SII在下肢动脉疾病(LEAD)患者中的价值。
方法：本研究共纳入271例诊断为LEAD的患者。收集患者的血液样品并分析生化变量和全血细胞计数参数。计算每个患者的SII值。动脉粥样硬化疾病的复杂性根据跨大西洋社会间共识（TASCII）分类进行分类。
结果：TASCCC-D组患者年龄大于TASCA-B组患者（63.06±9.24岁和60.85±8.75岁，分别)。两组的其他合并症具有可比性。血红蛋白水平和淋巴细胞计数明显降低，中性粒细胞,血小板计数,与TASCA-B病患者相比，TASCC-D病患者的SII值明显更高。SII与LEAD的严重程度显著相关(r=0.363,p<.001)。664.24的SII值预测TASCC-D疾病的敏感性和特异性分别为60.8%和73.3%,分别。多因素logistic回归分析结果显示,SII与血小板相比具有更高的比值比,中性粒细胞,和淋巴细胞计数。
结论：较高的SII可能表明更复杂的LEAD的可能性。就冠状动脉疾病和外周动脉疾病的相似病理生理学而言，这种关系似乎是合理的。
方法：本研究共纳入271例诊断为LEAD的患者。收集患者的血液样品并分析生化变量和全血细胞计数参数。计算每个患者的SII值。动脉粥样硬化疾病的复杂性根据跨大西洋社会间共识（TASCII）分类进行分类。
结果：TASCCC-D组患者年龄大于TASCA-B组患者（63.06±9.24岁和60.85±8.75岁，分别)。两组的其他合并症具有可比性。血红蛋白水平和淋巴细胞计数明显降低，中性粒细胞,血小板计数,与TASCA-B病患者相比，TASCC-D病患者的SII值明显更高。SII与LEAD的严重程度显著相关(r=0.363,p<.001)。664.24的SII值预测TASCC-D疾病的敏感性和特异性分别为60.8%和73.3%,分别。多因素logistic回归分析结果显示,SII与血小板相比具有更高的比值比,中性粒细胞,和淋巴细胞计数。
结论：较高的SII可能表明更复杂的LEAD的可能性。就冠状动脉疾病和外周动脉疾病的相似病理生理学而言，这种关系似乎是合理的。
