Abstract：
Throughout pregnancy, the maternal peripheral circulation contains valuable information reflecting pregnancy progression, detectable as tightly regulated immune dynamics. Local immune processes at the maternal-fetal interface and other reproductive and non-reproductive tissues are likely to be the pacemakers for this peripheral immune \"clock.\" This cellular immune status of pregnancy can be leveraged for the early risk assessment and prediction of spontaneous preterm birth (sPTB). Systems immunology approaches to sPTB subtypes and cross-tissue (local and peripheral) interactions, as well as integration of multiple biological data modalities promise to improve our understanding of preterm birth pathobiology and identify potential clinically actionable biomarkers.
摘要：
在整个怀孕期间,母体外周循环包含反映妊娠进展的有价值的信息，可检测为严格调节的免疫动力学。母胎界面和其他生殖和非生殖组织的局部免疫过程可能是这种外周免疫时钟的起搏器。“妊娠的这种细胞免疫状态可用于早期风险评估和自发性早产（sPTB）的预测。sPTB亚型和跨组织（局部和外周）相互作用的系统免疫学方法，以及多种生物学数据模式的整合有望提高我们对早产病理生物学的理解,并确定潜在的临床可操作的生物标志物.
