Abstract：
In recent years, Heated tobacco products (HTP) have gradually entered the market and become more and more popular with consumers because of their low risk (compared with traditional cigarette). With the increasing popularity and proportion of HTP in the international market, people pay more and more attention to the safety evaluation of HTP, but there is still a lack of systematic review of HTP safety research. In this review, the harmful components of HTP, multi-organ functional programming effects (including respiratory system, cardiovascular system, etc.), and mechanism of the effect generation (including oxidative stress, inflammatory response, etc.) were systematically reviewed, the safety effects of HTP and traditional cigarettes were compared in detail, and the shortcomings and future research directions in the field of HTP safety were discussed. In summary, this review conforms to the general trend of contemporary \"tobacco and health\", helps people to understand and evaluate HTP more systematically, and provides a strong theoretical support and literature basis for the tobacco industry to carry out HTP risk assessment and exposure improvement.
摘要：
近年来,加热型烟草制品（HTP）由于其风险较低（与传统卷烟相比），逐渐进入市场并越来越受到消费者的欢迎。随着HTP在国际市场上的日益普及和比重，HTP的安全性评价越来越受到人们的重视,但目前尚缺乏对HTP安全性研究的系统评价。在这次审查中,HTP的有害成分，多器官功能编程效应(包括呼吸系统，心血管系统,等。),和效应产生的机制(包括氧化应激，炎症反应，等。)进行了系统审查，详细比较了HTP和传统卷烟的安全效果，并对HTP安全领域存在的不足和未来的研究方向进行了探讨。总之,这篇综述符合当代“烟草与健康”的大趋势，帮助人们更系统地理解和评估HTP，为烟草行业开展HTP风险评估和暴露改进提供了有力的理论支持和文献依据。
