Abstract：
OBJECTIVE: This study aimed to explore the relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and the development of new-onset gallbladder stone disease (GSD) and to identify factors that influence the occurrence of new-onset GSD in patients with MASLD.
METHODS: In this retrospective case-control study, patients who underwent asymptomatic GSD screening during annual routine health check-ups at two hospitals in China between August 2017 and July 2022 were included. Patients with new-onset GSD and controls without GSD were matched 1:1 based on age, sex, race, occupation, diet, drinking habits, systolic blood pressure, diastolic blood pressure, and fasting blood glucose levels.
RESULTS: The study comprised 1200 patients with new-onset GSD and 1200 controls without GSD. Patients with new-onset GSD had higher rates of MASLD (33.8% vs. 22.2 %, P < 0.001) and hypercholesterolemia (12.6% vs. 7.2 %, P < 0.001) compared to controls. Waist circumference (WC) (OR = 1.042, 95 % CI: 1.022-1.063, P < 0.001), high-density lipoprotein cholesterol (HDL-c) (OR = 0.048, 95 % CI: 0.037-0.062, P < 0.001), triglycerides (OR = 0.819, 95 % CI: 0.699-0.958, P = 0.013), and hypercholesterolemia (OR = 5.023, 95 % CI: 2.735-9.225, P < 0.001) were independently associated with new-onset GSD. Among patients with MASLD, WC (OR = 1.075, 95 % CI: 1.026-1.127, P = 0.003), total cholesterol (TC) (OR = 2.094, 95 % CI: 1.259-3.484, P = 0.004), HDL-c (OR = 0.088, 95 % CI: 0.054-0.142, P < 0.001), and low-density lipoprotein cholesterol (LDL-c) (OR = 4.056, 95 % CI: 2.669-6.163, P < 0.001) were independently associated with new-onset GSD.
CONCLUSIONS: The findings indicate that hypercholesterolemia is independently associated with GSD. Among patients with MASLD, hypercholesterolemia also showed an independent association with GSD. Notably, this study is the first to identify serum LDL-c levels as potentially the most significant risk factor for GSD, highlighting that elevated LDL-c could serve as an important indicator for individuals with MASLD.
METHODS: In this retrospective case-control study, patients who underwent asymptomatic GSD screening during annual routine health check-ups at two hospitals in China between August 2017 and July 2022 were included. Patients with new-onset GSD and controls without GSD were matched 1:1 based on age, sex, race, occupation, diet, drinking habits, systolic blood pressure, diastolic blood pressure, and fasting blood glucose levels.
RESULTS: The study comprised 1200 patients with new-onset GSD and 1200 controls without GSD. Patients with new-onset GSD had higher rates of MASLD (33.8% vs. 22.2 %, P < 0.001) and hypercholesterolemia (12.6% vs. 7.2 %, P < 0.001) compared to controls. Waist circumference (WC) (OR = 1.042, 95 % CI: 1.022-1.063, P < 0.001), high-density lipoprotein cholesterol (HDL-c) (OR = 0.048, 95 % CI: 0.037-0.062, P < 0.001), triglycerides (OR = 0.819, 95 % CI: 0.699-0.958, P = 0.013), and hypercholesterolemia (OR = 5.023, 95 % CI: 2.735-9.225, P < 0.001) were independently associated with new-onset GSD. Among patients with MASLD, WC (OR = 1.075, 95 % CI: 1.026-1.127, P = 0.003), total cholesterol (TC) (OR = 2.094, 95 % CI: 1.259-3.484, P = 0.004), HDL-c (OR = 0.088, 95 % CI: 0.054-0.142, P < 0.001), and low-density lipoprotein cholesterol (LDL-c) (OR = 4.056, 95 % CI: 2.669-6.163, P < 0.001) were independently associated with new-onset GSD.
CONCLUSIONS: The findings indicate that hypercholesterolemia is independently associated with GSD. Among patients with MASLD, hypercholesterolemia also showed an independent association with GSD. Notably, this study is the first to identify serum LDL-c levels as potentially the most significant risk factor for GSD, highlighting that elevated LDL-c could serve as an important indicator for individuals with MASLD.
摘要：
目的：本研究旨在探讨代谢功能障碍相关的脂肪变性肝病(MASLD)与新发胆囊结石病(GSD)发生的关系及影响MASLD患者新发GSD发生的因素。
方法：在这项回顾性病例对照研究中，纳入了2017年8月至2022年7月在中国两家医院进行的年度常规健康检查期间接受无症状GSD筛查的患者.新发GSD患者和无GSD的对照组按年龄1:1匹配,性别,种族,职业,饮食，饮酒习惯,收缩压,舒张压,和空腹血糖水平。
结果：该研究包括1200例新发GSD患者和1200例无GSD的对照。新发GSD患者的MASLD发生率较高（33.8%vs.22.2%,P<0.001）和高胆固醇血症（12.6%vs.7.2%,P<0.001）与对照组相比。腰围(WC)(OR=1.042,95%CI:1.022-1.063,P<0.001),高密度脂蛋白胆固醇(HDL-c)(OR=0.048,95%CI:0.037-0.062,P<0.001),甘油三酯（OR=0.819，95%CI：0.699-0.958，P=0.013），高胆固醇血症（OR=5.023，95％CI：2.735-9.225，P<0.001）与新发GSD独立相关。在MASLD患者中，WC（OR=1.075，95%CI：1.026-1.127，P=0.003），总胆固醇(TC)(OR=2.094,95%CI:1.259-3.484,P=0.004),HDL-c(OR=0.088,95%CI:0.054-0.142,P<0.001),低密度脂蛋白胆固醇（LDL-c）（OR=4.056，95％CI：2.669-6.163，P<0.001）与新发GSD独立相关。
结论：研究结果表明高胆固醇血症与GSD独立相关。在MASLD患者中，高胆固醇血症也显示与GSD独立相关.值得注意的是,这项研究首次将血清LDL-c水平确定为GSD的潜在最重要的危险因素，强调LDL-c升高可以作为MASLD患者的重要指标。
方法：在这项回顾性病例对照研究中，纳入了2017年8月至2022年7月在中国两家医院进行的年度常规健康检查期间接受无症状GSD筛查的患者.新发GSD患者和无GSD的对照组按年龄1:1匹配,性别,种族,职业,饮食，饮酒习惯,收缩压,舒张压,和空腹血糖水平。
结果：该研究包括1200例新发GSD患者和1200例无GSD的对照。新发GSD患者的MASLD发生率较高（33.8%vs.22.2%,P<0.001）和高胆固醇血症（12.6%vs.7.2%,P<0.001）与对照组相比。腰围(WC)(OR=1.042,95%CI:1.022-1.063,P<0.001),高密度脂蛋白胆固醇(HDL-c)(OR=0.048,95%CI:0.037-0.062,P<0.001),甘油三酯（OR=0.819，95%CI：0.699-0.958，P=0.013），高胆固醇血症（OR=5.023，95％CI：2.735-9.225，P<0.001）与新发GSD独立相关。在MASLD患者中，WC（OR=1.075，95%CI：1.026-1.127，P=0.003），总胆固醇(TC)(OR=2.094,95%CI:1.259-3.484,P=0.004),HDL-c(OR=0.088,95%CI:0.054-0.142,P<0.001),低密度脂蛋白胆固醇（LDL-c）（OR=4.056，95％CI：2.669-6.163，P<0.001）与新发GSD独立相关。
结论：研究结果表明高胆固醇血症与GSD独立相关。在MASLD患者中，高胆固醇血症也显示与GSD独立相关.值得注意的是,这项研究首次将血清LDL-c水平确定为GSD的潜在最重要的危险因素，强调LDL-c升高可以作为MASLD患者的重要指标。
