METHODS: We retrospectively reviewed our pediatric neurosurgery database for patients who received LITT treatment between November 2019 and December 2023. We collected data on the indications for LITT, technical issues during the procedure, and clinical and radiological follow-up.
RESULTS: Three patients underwent 5 LITT procedures for pLGG. The lesion was thalamo-peduncular in one patient, cingulate in one, and deep parietal in one patient. Two patients had a previous open resection done and were diagnosed with pLGG. One patient underwent a stereotaxic biopsy during the LITT procedure that was non-diagnostic. The same patient underwent a later open resection of the tumor in the cingulate gyrus. There were no surgical complications and all patients were discharged home on the first post-operative day. The follow-up period was between 20 and 40 months. Radiological follow-up showed a progressive reduction of the tumor in patients with LGG.
CONCLUSIONS: Laser interstitial thermal therapy is a minimally invasive treatment that shows promise in treating deep-seated pLGG in children. The treatment has demonstrated a reduction in tumor volume, and the positive results continue over time. LITT can be used as an alternative treatment for tumors located in areas that are difficult to access surgically or in cases where other standard treatment options have failed.
方法:我们回顾性回顾了我们在2019年11月至2023年12月期间接受LITT治疗的儿童神经外科数据库。我们收集了LITT适应症的数据,过程中的技术问题,以及临床和放射学随访。
结果:3例患者接受了5次pLGG的LITT手术。一名患者的病变是丘脑-花梗,扣带回一个,和一个病人的深顶骨。两名患者先前进行了开放切除术,并被诊断为pLGG。一名患者在LITT手术期间接受了立体定位活检,但未诊断。同一患者随后对扣带回的肿瘤进行了开放性切除术。没有手术并发症,所有患者在术后第一天出院。随访时间为20至40个月。放射学随访显示LGG患者的肿瘤逐渐减少。
结论:激光间质热疗法是一种微创治疗,在治疗儿童深层pLGG方面显示出希望。治疗已证明肿瘤体积减小,随着时间的推移,积极的结果会持续下去。LITT可用作位于难以通过手术进入的区域或在其他标准治疗方案失败的情况下的肿瘤的替代治疗。