Abstract：
Herein, we report a spectroscopic study of N-acetyl-L-cysteine, an important antioxidant drug, using Fourier-transform microwave techniques and in isolated conditions. Two conformers are observed, where most stable structure adopts a cis disposition, and the second conformer has a lower abundance and adopts a trans disposition. The rotational constants and the barriers to methyl internal rotation are determined for each conformer, allowing a precise conformation identification. The results show that the cis form adopts an identical structure in the crystal, solution, and gas phases. Additionally, the structures are contrasted against those of cysteine.
摘要：
在这里，我们报道了N-乙酰-L-半胱氨酸的光谱学研究，一种重要的抗氧化药物，使用傅里叶变换微波技术和在孤立的条件下。观察到两种构象，最稳定的结构采用顺式结构，第二个构象的丰度较低，采用反式配置。确定每个构象的旋转常数和甲基内部旋转的势垒，允许精确的构象鉴定。结果表明，顺式晶体具有相同的结构，解决方案,和气相。此外,结构与半胱氨酸的结构形成对比。
