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Abstract：
BACKGROUND: This study aimed to compare the diagnostic value of [68 Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT imaging for primary lesions and metastatic lymph nodes in patients with tonsil cancer.
METHODS: Twenty-one tonsil cancer patients who underwent [68 Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT scans within two weeks in our centre were retrospectively enrolled. The maximum standardized uptake value (SUVmax) and tumor-to-background ratio (TBR) of the two tracers were compared by using the Mann‒Whitney U test. In addition, the sensitivity, specificity, and accuracy of the two methods for diagnosing metastatic lymph nodes were analysed.
RESULTS: In detecting primary lesions, the efficiency was higher for [68 Ga]Ga-DOTA-FAPI-04 PET/CT (20/22) than for [18F]FDG PET/CT (9/22). Although [68 Ga]Ga-DOTA-FAPI-04 uptake (SUVmax, 5.03 ± 4.06) was lower than [18F]FDG uptake (SUVmax, 7.90 ± 4.84, P = 0.006), [68 Ga]Ga-DOTA-FAPI-04 improved the distinction between the primary tumor and contralateral normal tonsillar tissue. The TBR was significantly higher for [68 Ga]Ga-DOTA-FAPI-04 PET/CT (3.19 ± 2.06) than for [18F]FDG PET/CT (1.89 ± 1.80) (p < 0.001). In lymph node analysis, SUVmax and TBR were not significantly different between [68 Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT (7.67 ± 5.88 vs. 8.36 ± 6.15, P = 0.498 and 5.56 ± 4.02 vs. 4.26 ± 3.16, P = 0.123, respectively). The specificity and accuracy of [68 Ga]Ga-DOTA-FAPI-04 PET/CT were higher than those of [18F]FDG PET/CT in diagnosing metastatic cervical lymph nodes (all P < 0.05).
CONCLUSIONS: The availability of [68 Ga]Ga-DOTA-FAPI-04 complements the diagnostic results of [18F]FDG by improving the detection rate of primary lesions and the diagnostic accuracy of cervical metastatic lymph nodes in tonsil cancer compared to [18F]FDG.
METHODS: Twenty-one tonsil cancer patients who underwent [68 Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT scans within two weeks in our centre were retrospectively enrolled. The maximum standardized uptake value (SUVmax) and tumor-to-background ratio (TBR) of the two tracers were compared by using the Mann‒Whitney U test. In addition, the sensitivity, specificity, and accuracy of the two methods for diagnosing metastatic lymph nodes were analysed.
RESULTS: In detecting primary lesions, the efficiency was higher for [68 Ga]Ga-DOTA-FAPI-04 PET/CT (20/22) than for [18F]FDG PET/CT (9/22). Although [68 Ga]Ga-DOTA-FAPI-04 uptake (SUVmax, 5.03 ± 4.06) was lower than [18F]FDG uptake (SUVmax, 7.90 ± 4.84, P = 0.006), [68 Ga]Ga-DOTA-FAPI-04 improved the distinction between the primary tumor and contralateral normal tonsillar tissue. The TBR was significantly higher for [68 Ga]Ga-DOTA-FAPI-04 PET/CT (3.19 ± 2.06) than for [18F]FDG PET/CT (1.89 ± 1.80) (p < 0.001). In lymph node analysis, SUVmax and TBR were not significantly different between [68 Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT (7.67 ± 5.88 vs. 8.36 ± 6.15, P = 0.498 and 5.56 ± 4.02 vs. 4.26 ± 3.16, P = 0.123, respectively). The specificity and accuracy of [68 Ga]Ga-DOTA-FAPI-04 PET/CT were higher than those of [18F]FDG PET/CT in diagnosing metastatic cervical lymph nodes (all P < 0.05).
CONCLUSIONS: The availability of [68 Ga]Ga-DOTA-FAPI-04 complements the diagnostic results of [18F]FDG by improving the detection rate of primary lesions and the diagnostic accuracy of cervical metastatic lymph nodes in tonsil cancer compared to [18F]FDG.
摘要：
背景：本研究旨在比较[68Ga]Ga-DOTA-FAPI-04和[18F]FDGPET/CT显像对扁桃体癌患者原发灶和转移淋巴结的诊断价值。
方法：回顾性纳入21例扁桃体癌患者，这些患者在我们中心两周内接受了[68Ga]Ga-DOTA-FAPI-04和[18F]FDGPET/CT扫描。使用Mann-WhitneyU检验比较了两种示踪剂的最大标准化摄取值（SUVmax）和肿瘤背景比（TBR）。此外,灵敏度,特异性，并分析了两种方法诊断转移性淋巴结的准确性。
结果：在检测原发性病变时，[68Ga]Ga-DOTA-FAPI-04PET/CT(20/22)的效率高于[18F]FDGPET/CT(9/22)。尽管[68Ga]Ga-DOTA-FAPI-04摄取(SUVmax，5.03±4.06)低于[18F]FDG摄取(SUVmax，7.90±4.84,P=0.006),[68Ga]Ga-DOTA-FAPI-04改善了原发性肿瘤和对侧正常扁桃体组织之间的区别。[68Ga]Ga-DOTA-FAPI-04PET/CT的TBR(3.19±2.06)显著高于[18F]FDGPET/CT(1.89±1.80)(p<0.001)。在淋巴结分析中，[68Ga]Ga-DOTA-FAPI-04和[18F]FDGPET/CT之间的SUVmax和TBR没有显着差异（7.67±5.88vs.8.36±6.15，P=0.498和5.56±4.02。4.26±3.16，P=0.123）。[68Ga]Ga-DOTA-FAPI-04PET/CT诊断颈部淋巴结转移的特异性和准确性均高于[18F]FDGPET/CT(均P<0.05)。
结论：与[18F]FDG相比，[68Ga]Ga-DOTA-FAPI-04的可用性提高了[18F]FDG的原发灶检出率和颈部转移淋巴结的诊断准确性，从而补充了[18F]FDG的诊断结果。
方法：回顾性纳入21例扁桃体癌患者，这些患者在我们中心两周内接受了[68Ga]Ga-DOTA-FAPI-04和[18F]FDGPET/CT扫描。使用Mann-WhitneyU检验比较了两种示踪剂的最大标准化摄取值（SUVmax）和肿瘤背景比（TBR）。此外,灵敏度,特异性，并分析了两种方法诊断转移性淋巴结的准确性。
结果：在检测原发性病变时，[68Ga]Ga-DOTA-FAPI-04PET/CT(20/22)的效率高于[18F]FDGPET/CT(9/22)。尽管[68Ga]Ga-DOTA-FAPI-04摄取(SUVmax，5.03±4.06)低于[18F]FDG摄取(SUVmax，7.90±4.84,P=0.006),[68Ga]Ga-DOTA-FAPI-04改善了原发性肿瘤和对侧正常扁桃体组织之间的区别。[68Ga]Ga-DOTA-FAPI-04PET/CT的TBR(3.19±2.06)显著高于[18F]FDGPET/CT(1.89±1.80)(p<0.001)。在淋巴结分析中，[68Ga]Ga-DOTA-FAPI-04和[18F]FDGPET/CT之间的SUVmax和TBR没有显着差异（7.67±5.88vs.8.36±6.15，P=0.498和5.56±4.02。4.26±3.16，P=0.123）。[68Ga]Ga-DOTA-FAPI-04PET/CT诊断颈部淋巴结转移的特异性和准确性均高于[18F]FDGPET/CT(均P<0.05)。
结论：与[18F]FDG相比，[68Ga]Ga-DOTA-FAPI-04的可用性提高了[18F]FDG的原发灶检出率和颈部转移淋巴结的诊断准确性，从而补充了[18F]FDG的诊断结果。
