PDF(Pubmed)
Abstract：
Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular content release. Originally investigated as a targeted therapy for cancer cells carrying oncogenic RAS mutations, ferroptosis induction now exhibits potential to complement chemotherapy, immunotherapy, and radiotherapy in various cancer types. However, it can lead to side effects, including immune cell death, bone marrow impairment, liver and kidney damage, cachexia (severe weight loss and muscle wasting), and secondary tumorigenesis. In this review, we discuss the advantages and offer an overview of the diverse range of documented side effects. Furthermore, we examine the underlying mechanisms and explore potential strategies for side effect mitigation.
摘要：
Ferroptosis是一种以铁积累和不受控制的脂质过氧化为特征的调节性细胞死亡。导致质膜破裂和细胞内内容物释放。最初研究作为携带致癌RAS突变的癌细胞的靶向治疗，铁凋亡诱导现在显示出补充化疗的潜力，免疫疗法，以及各种癌症类型的放射治疗。然而,会导致副作用,包括免疫细胞死亡，骨髓损伤,肝肾损害,恶病质（严重的体重减轻和肌肉萎缩），和继发性肿瘤发生。在这次审查中,我们将讨论其优势，并概述各种已记录的副作用。此外，我们研究了潜在的机制，并探索了缓解副作用的潜在策略。
