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Abstract：
BACKGROUND: Medullary sponge kidney (MSK)is rare in association with glomerulonephritis. We report a patient with medullary sponge kidney, and the kidney biopsy revealed a diagnosis of IgA nephropathy.
METHODS: A 27-year-old female presented with hematuria and proteinuria, and imaging studies indicated the presence of medullary spongy kidney. With appropriate preparation, a kidney biopsy was performed. Considering the patient\'s clinical and pathological characteristics, the final diagnosis was determined to be medullary sponge kidney associated by IgA nephropathy. The combination of corticosteroids and angiotensin receptor blockers (ARBs) proved to be significantly effective in reducing proteinuria in the current case. To the best of our knowledge, this is the first reported case that demonstrates the coexistence of MSK and IgA nephropathy.
CONCLUSIONS: Administering precise therapy based on renal pathology can potentially enhance outcomes for patients with renal conditions, necessitating the need for clinicians to be vigilant about differential diagnosis in order to reduce the rates of missed diagnoses and misdiagnosis.
METHODS: A 27-year-old female presented with hematuria and proteinuria, and imaging studies indicated the presence of medullary spongy kidney. With appropriate preparation, a kidney biopsy was performed. Considering the patient\'s clinical and pathological characteristics, the final diagnosis was determined to be medullary sponge kidney associated by IgA nephropathy. The combination of corticosteroids and angiotensin receptor blockers (ARBs) proved to be significantly effective in reducing proteinuria in the current case. To the best of our knowledge, this is the first reported case that demonstrates the coexistence of MSK and IgA nephropathy.
CONCLUSIONS: Administering precise therapy based on renal pathology can potentially enhance outcomes for patients with renal conditions, necessitating the need for clinicians to be vigilant about differential diagnosis in order to reduce the rates of missed diagnoses and misdiagnosis.
摘要：
背景：髓质海绵肾（MSK）很少与肾小球肾炎相关。我们报告了一个髓样海绵肾患者，肾活检显示诊断为IgA肾病。
方法：一名27岁女性，表现为血尿和蛋白尿，影像学检查显示存在髓质海绵状肾。经过适当的准备，进行了肾活检.考虑到患者的临床和病理特点,最终诊断为与IgA肾病相关的髓质海绵肾。在当前病例中，皮质类固醇和血管紧张素受体阻滞剂（ARB）的组合被证明在减少蛋白尿方面显着有效。据我们所知,这是首例报道的MSK和IgA肾病并存的病例.
结论：基于肾脏病理的精确治疗可能会提高肾脏疾病患者的预后，需要临床医生对鉴别诊断保持警惕，以减少漏诊和误诊率。
方法：一名27岁女性，表现为血尿和蛋白尿，影像学检查显示存在髓质海绵状肾。经过适当的准备，进行了肾活检.考虑到患者的临床和病理特点,最终诊断为与IgA肾病相关的髓质海绵肾。在当前病例中，皮质类固醇和血管紧张素受体阻滞剂（ARB）的组合被证明在减少蛋白尿方面显着有效。据我们所知,这是首例报道的MSK和IgA肾病并存的病例.
结论：基于肾脏病理的精确治疗可能会提高肾脏疾病患者的预后，需要临床医生对鉴别诊断保持警惕，以减少漏诊和误诊率。
