Abstract：
Immunotherapy has emerged as a promising approach to cancer treatment, offering improved survival rates and enhanced patients\' quality of life. However, realizing the full potential of immunotherapy in clinical practice remains a challenge, as there is still plenty of room for modulating the complexity of the human immune system in favor of an antitumor immunogenicity. Nanotechnology, with its unique properties, holds promise in augmenting the efficacy of cancer immunotherapies in biotherapeutic protection and site- and time-controlled delivery of the immune modulator biologicals. Polymeric nanoparticles are promising biomaterials among different nanocarriers thanks to their robustness, versatility, and cost-efficient design and production. This perspective paper overviews critical concepts in nanometric advanced delivery systems applied to cancer immunotherapy. We focus on a detailed exploration of the current state of the art and trends in using poly(beta-aminoester) (pBAE) polymers for nucleic acid-based antitumor immunotherapies. Through different examples of the use of pBAE polymers reported in the literature, we revise the main advantages these polymers offer and some challenges to overcome. Finally, the paper provides insights and predictions on the path toward the clinical implementation of cancer nano-immunotherapies, highlighting the potential of pBAE polymers for advancements in this field.
摘要：
免疫疗法已经成为一种有希望的癌症治疗方法，提供提高的生存率和提高患者的生活质量。然而,在临床实践中实现免疫治疗的全部潜力仍然是一个挑战，因为仍然有足够的空间来调节人类免疫系统的复杂性，以支持抗肿瘤免疫原性。纳米技术，凭借其独特的属性，有望增强癌症免疫疗法在生物治疗保护以及免疫调节剂生物制剂的位点和时间控制递送中的功效。聚合物纳米粒子是有前途的生物材料在不同的纳米载体由于其鲁棒性，多功能性，和成本效益的设计和生产。这篇透视论文概述了应用于癌症免疫治疗的纳米先进递送系统的关键概念。我们专注于对当前技术水平的详细探索，以及将聚（β-氨基酯）（pBAE）聚合物用于基于核酸的抗肿瘤免疫疗法的趋势。通过文献中报道的使用pBAE聚合物的不同实例，我们修改了这些聚合物提供的主要优势和一些需要克服的挑战。最后,本文提供了对癌症纳米免疫疗法的临床实施路径的见解和预测，强调pBAE聚合物在这一领域取得进展的潜力。
