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Abstract：
Hidradenitis suppurativa (HS) is a debilitating chronic skin disorder characterized by painful inflammatory nodules, abscesses and sinus tracts involving intertriginous areas and has an adverse impact on patient quality of life. Over the past decade, the therapeutic options of HS have increased significantly to comprise multiple modalities, including topical medication, systemic therapies (mainly antibiotics, retinoids, and biologics), surgical approaches, and lifestyle modifications. Biologics alone or in combination with surgery remain the treatment of choice for moderate to severe disease. However, non-biologic therapies (including retinoids) may be used as monotherapy for mild disease and in combination with biologics and surgical treatment in moderate to severe disease. Retinoids, specifically isotretinoin, acitretin, and alitretinoin, are historically used in the management of HS, supported by anecdotal evidence and with variable treatment response. Although the current American and European guidelines offer different recommendations on the use of retinoids in HS, retinoids remain a valuable ally in HS management. This review provides a comprehensive analysis of the current scientific literature on retinoid therapy (topical and systemic) in HS, highlighting disparities in mechanisms of action, efficacy, and safety to clarify their role in HS treatment.
摘要：
化脓性汗腺炎（HS）是一种使人衰弱的慢性皮肤病，其特征是疼痛的炎性结节，脓肿和窦道累及三生区域，对患者的生活质量有不利影响。在过去的十年里，HS的治疗选择显着增加，包括多种模式，包括局部用药,全身疗法（主要是抗生素，类维生素A，和生物制品)，手术方法,和生活方式的改变。单独或与手术组合的生物制剂仍然是中度至重度疾病的治疗选择。然而,非生物疗法（包括类维生素A）可用作轻度疾病的单一疗法，并与生物制剂和外科治疗联合用于中度至重度疾病。维甲酸,特别是异维甲酸，阿维酮,和阿利维甲酸,在历史上用于HS的管理，得到轶事证据和可变治疗反应的支持。尽管当前的美国和欧洲指南对在HS中使用类维生素A提供了不同的建议，类维生素A在HS管理中仍然是一个有价值的盟友.这篇综述提供了关于HS中类视黄醇治疗（局部和全身）的当前科学文献的全面分析，突出行动机制的差异，功效,和安全性，以阐明其在HS治疗中的作用。
