Abstract：
Biomarkers are crucial physiological and pathological indicators in the host. Over the years, numerous detection methods have been developed for biomarkers, given their significant potential in various biological and biomedical applications. Among these, the detection system based on functionalized DNA origami has emerged as a promising approach due to its precise control over sensing modules, enabling sensitive, specific, and programmable biomarker detection. We summarize the advancements in biomarker detection using functionalized DNA origami, focusing on strategies for DNA origami functionalization, mechanisms of biomarker recognition, and applications in disease diagnosis and monitoring. These applications are organized into sections based on the type of biomarkers - nucleic acids, proteins, small molecules, and ions - and concludes with a discussion on the advantages and challenges associated with using functionalized DNA origami systems for biomarker detection.
摘要：
生物标志物是宿主体内重要的生理和病理指标。多年来,已经开发了许多生物标志物的检测方法，考虑到它们在各种生物和生物医学应用中的巨大潜力。其中,基于功能化DNA折纸的检测系统由于其对传感模块的精确控制而成为一种有前途的方法，启用敏感，具体,和可编程生物标志物检测。我们总结了使用功能化DNA折纸进行生物标志物检测的进展，专注于DNA折纸功能化的策略，生物标志物识别的机制，以及在疾病诊断和监测中的应用。这些应用根据生物标志物的类型-核酸被组织成部分，蛋白质，小分子,和离子-最后讨论了与使用功能化DNA折纸系统进行生物标志物检测相关的优势和挑战。
