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Abstract：
Inflammation and dyslipidemia are critical inducing factors of atherosclerosis. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and control the expression of multiple genes that are involved in lipid metabolism and inflammatory responses. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis therapy. Natural products are structural diversity and have a good safety. Recent studies find that natural herbs and compounds exhibit attractive therapeutic effects on atherosclerosis by alleviating hyperlipidemia and inflammation through modulation of PPARs. Importantly, the preparation of natural products generally causes significantly lower environmental pollution compared to that of synthesized chemical compounds. Therefore, it is interesting to discover novel PPAR modulator and develop alternative strategies for atherosclerosis therapy based on natural herbs and compounds. This article reviews recent findings, mainly from the year of 2020 to present, about the roles of natural herbs and compounds in regulation of PPARs and their therapeutic effects on atherosclerosis. This article provides alternative strategies and theoretical basis for atherosclerosis therapy using natural herbs and compounds by targeting PPARs, and offers valuable information for researchers that are interested in developing novel PPAR modulators.
摘要：
炎症和血脂异常是动脉粥样硬化的关键诱发因素。过氧化物酶体增殖物激活受体（PPAR）是配体激活的转录因子，可控制多个参与脂质代谢和炎症反应的基因的表达。然而,合成的PPAR激动剂在动脉粥样硬化治疗中表现出相反的治疗效果和各种副作用。天然产物结构多样，具有良好的安全性。最近的研究发现，天然草药和化合物通过调节PPAR来减轻高脂血症和炎症，对动脉粥样硬化具有诱人的治疗作用。重要的是,与合成的化合物相比，天然产物的制备通常会导致更低的环境污染。因此,发现新的PPAR调节剂并开发基于天然草药和化合物的动脉粥样硬化治疗替代策略是很有趣的。本文回顾了最近的发现，主要从2020年到现在，关于天然草药和化合物在调节PPARs中的作用及其对动脉粥样硬化的治疗作用。本文提供了以PPARs为靶点的天然草药和化合物治疗动脉粥样硬化的替代策略和理论基础。并为有兴趣开发新的PPAR调节剂的研究人员提供有价值的信息。
