PDF(Pubmed)
Abstract：
Bis-octanoyl (R)-1,3-butanediol (BO-BD) is a novel ketone ester (KE) ingredient which increases blood beta-hydroxybutyrate (BHB) concentrations rapidly after ingestion. KE is hypothesized to have beneficial metabolic effects on health and performance, especially in older adults. Whilst many studies have investigated the ketogenic effect of KE in young adults, they have not been studied in an exclusively older adult population, for whom age-related differences in body composition and metabolism may alter the effects. This randomized, observational, open-label study in healthy older adults (n = 30, 50% male, age = 76.5 years, BMI = 25.2 kg/m2) aimed to elucidate acute tolerance, blood BHB and blood glucose concentrations for 4 hours following consumption of either 12.5 or 25 g of BO-BD formulated firstly as a ready-to-drink beverage (n = 30), then as a re-constituted powder (n = 21), taken with a standard meal. Both serving sizes and formulations of BO-BD were well tolerated, and increased blood BHB, inducing nutritional ketosis (≥ 0.5mM) that lasted until the end of the study. Ketosis was dose responsive; peak BHB concentration (Cmax) and incremental area under the curve (iAUC) were significantly greater with 25 g compared to 12.5 g of BO-BD in both formulations. There were no significant differences in Cmax or iAUC between formulations. Blood glucose increased in all conditions following the meal; there were no consistent significant differences in glucose response between conditions. These results demonstrate that both powder and beverage formulations of the novel KE, BO-BD, induce ketosis in healthy older adults, facilitating future research on functional effects of this ingredient in aging.
摘要：
双辛酰基(R)-1,3-丁二醇(BO-BD)是一种新型酮酯(KE)成分,其在摄入后迅速增加血液β-羟基丁酸(BHB)浓度。假设KE对健康和表现有有益的代谢影响，尤其是老年人。虽然许多研究已经调查了KE在年轻人中的生酮作用，它们还没有在完全老年人群中进行研究，与年龄相关的身体成分和新陈代谢差异可能会改变这些影响。这个随机的，观察,健康老年人的开放标签研究(n=30，50%男性，年龄=76.5岁，BMI=25.2kg/m2)旨在阐明急性耐受性，首先作为即饮饮料配制的12.5或25gBO-BD后4小时的血液BHB和血糖浓度（n=30），然后作为重组粉末(n=21)，与标准餐一起服用。BO-BD的份量和配方均具有良好的耐受性，增加血液BHB，诱导营养酮症（≥0.5mM），持续到研究结束。酮病是剂量响应的;与两种制剂中的12.5gBO-BD相比,25g的峰值BHB浓度(Cmax)和曲线下面积增量(iAUC)显著更大。制剂之间的Cmax或iAUC没有显著差异。餐后所有条件下的血糖均增加；条件之间的葡萄糖反应没有一致的显着差异。这些结果表明，新型KE的粉末和饮料配方，BO-BD,在健康的老年人中诱发酮症，促进对这种成分在衰老中的功能作用的未来研究。
