PDF(Pubmed)
Abstract：
Working life is associated with lifestyle, screening uptake, and occupational health risks that may explain differences in cancer onset. To better understand the association between working life and cancer risk, we need to account for the entire employment history. We investigated whether lifetime employment trajectories are associated with cancer risk. We used data from 6,809 women and 5,716 men, average age 70 years, from the Survey of Health, Ageing, and Retirement in Europe. Employment history from age 16 to 65 was collected retrospectively using a life calendar and trajectories were constructed using sequence analysis. Associations between employment trajectories and self-reported cancer were assessed using logistic regression. We identified eight employment trajectories for women and two for men. Among women, the risk of cancer was higher in the trajectories \"Mainly full-time to home/family\", \"Full-time or home/family to part-time\", \"Mainly full-time\", and \"Other\" compared with the \"Mainly home/family\" trajectory. Among men, the risk of cancer was lower in the \"Mainly self-employment\" trajectory compared with \"Mainly full-time\". We could show how employment trajectories were associated with cancer risk, underlining the potential of sequence analysis for life course epidemiology. More research is needed to understand these associations and determine if causal relationships exist.
摘要：
工作生活与生活方式有关，筛选摄取，和职业健康风险可以解释癌症发病的差异。为了更好地理解工作寿命和癌症风险之间的关系，我们需要考虑整个就业历史。我们调查了终身就业轨迹是否与癌症风险相关。我们使用了6,809名女性和5,716名男性的数据，平均年龄70岁,根据健康调查，老龄化,退休在欧洲。使用生活日历回顾性收集16至65岁的就业历史，并使用序列分析构建轨迹。使用逻辑回归评估就业轨迹与自我报告的癌症之间的关联。我们确定了女性的八个就业轨迹和男性的两个就业轨迹。在女性中,癌症的风险更高，“主要是全职家庭/家庭”，\“全职或家庭/家庭到兼职\”，“主要是全职”，和“其他”与“主要是家庭/家庭”轨迹相比。在男性中,与“主要是全职”相比，“主要是自营职业”的癌症风险较低。我们可以展示就业轨迹如何与癌症风险相关，强调序列分析对生命过程流行病学的潜力。需要更多的研究来理解这些关联并确定是否存在因果关系。
