METHODS: Monocentric cross-sectional observational study. Consecutive patients affected by CRS with or without nasal polyps or by SD were considered eligible. At referral, each patient underwent nasal endoscopy for clinical diagnosis and had to fill in the Hospital Anxiety and Depression Scale (HADS), the Sinonasal Outcome Test-22 (SNOT-22), and the Visual Analogue Scale (VAS) for global nasal symptoms. The population was grouped according to disease and age.
RESULTS: One hundred fifty patients were enrolled. We observed a statistically significant difference in mean HADS score between patients affected by CRS with nasal polyps and those suffering from CRS without nasal polyps or SD both in the overall population and by age groups. Nevertheless, there was no significant difference in the HADS score between younger patients affected by CRS and SD. The mean HADS score was significantly higher in younger patients affected by SD compared to older. Furthermore, we observed an inverse correlation between age and HADS score in each disease group, statistically significant for SD. On the contrary, in the overall population, HADS score and patient-related outcomes (PROs) were directly correlated. Conclusions: In the era of personalized medicine, our work remarks on the critical impact of anxiety and depression on the quality of life (QoL) of patients affected by sinonasal conditions. According to our results, age affects patient-reported outcomes (PROs) and should, therefore, be enhanced in the therapeutic decision process.
方法:单中心横断面观察研究。连续患有或不患有鼻息肉或SD的CRS患者被认为是合格的。在转诊时,每位患者都接受了鼻内镜检查以进行临床诊断,并必须填写医院焦虑和抑郁量表(HADS),鼻窦结果测试-22(SNOT-22),和视觉模拟评分(VAS)的整体鼻部症状。根据疾病和年龄对人群进行分组。
结果:纳入150名患者。我们观察到,在总体人群和年龄组中,患有鼻息肉的CRS患者与患有无鼻息肉或SD的CRS患者之间的平均HADS评分存在统计学上的显着差异。然而,受CRS和SD影响的年轻患者之间的HADS评分没有显着差异。与老年人相比,受SD影响的年轻患者的平均HADS评分明显更高。此外,我们观察到每个疾病组的年龄与HADS评分呈负相关,SD具有统计学意义。相反,在总人口中,HADS评分和患者相关结果(PRO)直接相关。结论:在个性化医疗时代,我们的工作是关于焦虑和抑郁对受鼻窦疾病影响的患者生活质量(QoL)的关键影响。根据我们的结果,年龄影响患者报告的结果(PRO),因此,在治疗决策过程中得到加强。