PDF(Pubmed)
Abstract：
UNASSIGNED: The inflammation plays a role in the pathophysiology of type-2 diabetes progression, and the mechanism remains unclear. The systemic immune-inflammation index (SII) is a novel inflammatory marker for type 2 diabetes patients and integrates multiple indicators in complete blood counts and routine blood tests.
UNASSIGNED: Since there is no international diagnostic standard for dry eye disease (DED), this study uses low-cost inflammatory blood biomarkers to investigate the correlation between SII and DM2-DED and determine the diagnosis indices of other biomarkers in DM2-DED.
UNASSIGNED: A case-control retrospective analysis of totel patients n = 293 randomly selected and categorized into four groups: DED, DM2, DM2-DED, and healthy subjects. Demographic and blood biomarker variables were classified as categorical and continuous variables. The platelet-to-lymphocyte ratio (PLR), lymphocytes-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio (NLR), and SII were calculated platelet count multiply by NLR and analyzed for their correlation for all groups.
UNASSIGNED: Focusing on DM2-DED patients was more common in females, 59.6%, than in males, 40.2%. The mean ages were 60.7 ± 11.85 years, a statistically significant difference with all groups. In the study group DM2-DED, there was an increase in all blood markers compared to all remaining groups except PLR. Only neutrophil, hemoglobin A1c (HbA1c), and fasting blood sugar levels were statistically significant differences in DM2-DED patients (p > 0.001, p < 0.001, and p < 0.001, respectively) compared to all groups. There was a positive correlation between HbA1c and PLR, HbA1c and NLR, and HbA1c and SII (r = 0.037, p = 0.705; r = 0.031, p = 0.754; and r = 0.066, p < 0.501, respectively) in the DM2-DED group.
UNASSIGNED: This study demonstrated that elevated SII values were linked to elevated HbA1c in DM2-DED patients. The potential of SII and HbA1c as early diagnostic indicators for ocular problems associated with diabetes mellitus is highlighted by their favorable connection in diagnosing DM2-DED.
UNASSIGNED: Since there is no international diagnostic standard for dry eye disease (DED), this study uses low-cost inflammatory blood biomarkers to investigate the correlation between SII and DM2-DED and determine the diagnosis indices of other biomarkers in DM2-DED.
UNASSIGNED: A case-control retrospective analysis of totel patients n = 293 randomly selected and categorized into four groups: DED, DM2, DM2-DED, and healthy subjects. Demographic and blood biomarker variables were classified as categorical and continuous variables. The platelet-to-lymphocyte ratio (PLR), lymphocytes-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio (NLR), and SII were calculated platelet count multiply by NLR and analyzed for their correlation for all groups.
UNASSIGNED: Focusing on DM2-DED patients was more common in females, 59.6%, than in males, 40.2%. The mean ages were 60.7 ± 11.85 years, a statistically significant difference with all groups. In the study group DM2-DED, there was an increase in all blood markers compared to all remaining groups except PLR. Only neutrophil, hemoglobin A1c (HbA1c), and fasting blood sugar levels were statistically significant differences in DM2-DED patients (p > 0.001, p < 0.001, and p < 0.001, respectively) compared to all groups. There was a positive correlation between HbA1c and PLR, HbA1c and NLR, and HbA1c and SII (r = 0.037, p = 0.705; r = 0.031, p = 0.754; and r = 0.066, p < 0.501, respectively) in the DM2-DED group.
UNASSIGNED: This study demonstrated that elevated SII values were linked to elevated HbA1c in DM2-DED patients. The potential of SII and HbA1c as early diagnostic indicators for ocular problems associated with diabetes mellitus is highlighted by their favorable connection in diagnosing DM2-DED.
摘要：
■炎症在2型糖尿病进展的病理生理学中起作用，机制尚不清楚。全身免疫炎症指数（SII）是2型糖尿病患者的一种新型炎症标志物，可整合全血细胞计数和常规血液检查中的多种指标。
■由于没有干眼症（DED）的国际诊断标准，本研究使用低成本炎性血液生物标志物来研究SII与DM2-DED的相关性,并确定DM2-DED中其他生物标志物的诊断指标.
■对随机选择的293名患者进行病例对照回顾性分析，分为四组：DED，DM2,DM2-DED,和健康的受试者。人口统计学和血液生物标志物变量被分类为分类变量和连续变量。血小板与淋巴细胞比率（PLR），淋巴细胞与淋巴细胞的比例，中性粒细胞与淋巴细胞比率（NLR），和SII计算血小板计数乘以NLR，并分析所有组的相关性。
■关注DM2-DED患者在女性中更为常见，59.6%,比男性，40.2%。平均年龄为60.7±11.85岁，所有组的差异具有统计学意义。研究组DM2-DED,与除PLR以外的其余所有组相比,所有血液标志物均有增加.只有中性粒细胞,血红蛋白A1c（HbA1c），与所有组相比，DM2-DED患者的空腹血糖水平具有统计学意义（分别为p>0.001，p<0.001和p<0.001）。HbA1c与PLR呈正相关,HbA1c和NLR，DM2-DED组的HbA1c和SII（分别为r=0.037，p=0.705；r=0.031，p=0.754；r=0.066，p<0.501）。
■这项研究表明，在DM2-DED患者中，SII值升高与HbA1c升高有关。SII和HbA1c作为与糖尿病相关的眼部问题的早期诊断指标的潜力突出了它们在诊断DM2-DED中的有利联系。
■由于没有干眼症（DED）的国际诊断标准，本研究使用低成本炎性血液生物标志物来研究SII与DM2-DED的相关性,并确定DM2-DED中其他生物标志物的诊断指标.
■对随机选择的293名患者进行病例对照回顾性分析，分为四组：DED，DM2,DM2-DED,和健康的受试者。人口统计学和血液生物标志物变量被分类为分类变量和连续变量。血小板与淋巴细胞比率（PLR），淋巴细胞与淋巴细胞的比例，中性粒细胞与淋巴细胞比率（NLR），和SII计算血小板计数乘以NLR，并分析所有组的相关性。
■关注DM2-DED患者在女性中更为常见，59.6%,比男性，40.2%。平均年龄为60.7±11.85岁，所有组的差异具有统计学意义。研究组DM2-DED,与除PLR以外的其余所有组相比,所有血液标志物均有增加.只有中性粒细胞,血红蛋白A1c（HbA1c），与所有组相比，DM2-DED患者的空腹血糖水平具有统计学意义（分别为p>0.001，p<0.001和p<0.001）。HbA1c与PLR呈正相关,HbA1c和NLR，DM2-DED组的HbA1c和SII（分别为r=0.037，p=0.705；r=0.031，p=0.754；r=0.066，p<0.501）。
■这项研究表明，在DM2-DED患者中，SII值升高与HbA1c升高有关。SII和HbA1c作为与糖尿病相关的眼部问题的早期诊断指标的潜力突出了它们在诊断DM2-DED中的有利联系。
