PDF(Pubmed)
Abstract：
OBJECTIVE: To identify patients with type 2 diabetes mellitus (T2DM) with no history of fracture or osteoporosis treatment who are at risk of bone complications through the assessment of bone quality and quantity.
METHODS: Of the outpatients attending our clinic during 2021 to 2022, we retrospectively enrolled 137 (men/women: 85/52, median age: 65 years) consecutive patients aged ≥40 years who had T2DM but no history of fracture or osteoporosis treatment. The lumbar spine and femoral neck bone mineral density and the trabecular bone score were determined using dual-energy X-ray absorptiometry. Independent factors associated with bone disease were identified using logistic regression analysis, and odds ratios (ORs) were calculated.
RESULTS: Age and female sex were significantly associated with high ORs for development of bone disease. The integrated risk of bone complications was nearly 40-fold higher in older (≥65 years) women than in younger (<65 years) men. This difference remained after adjustment for the duration of T2DM, body mass index, and HbA1c level.
CONCLUSIONS: Older women have the highest risk of osteopenia and osteoporosis among patients with T2DM who have no history of fracture or osteoporosis treatment. These patients should undergo intensive monitoring for bone fragility from an early stage of their disease.
METHODS: Of the outpatients attending our clinic during 2021 to 2022, we retrospectively enrolled 137 (men/women: 85/52, median age: 65 years) consecutive patients aged ≥40 years who had T2DM but no history of fracture or osteoporosis treatment. The lumbar spine and femoral neck bone mineral density and the trabecular bone score were determined using dual-energy X-ray absorptiometry. Independent factors associated with bone disease were identified using logistic regression analysis, and odds ratios (ORs) were calculated.
RESULTS: Age and female sex were significantly associated with high ORs for development of bone disease. The integrated risk of bone complications was nearly 40-fold higher in older (≥65 years) women than in younger (<65 years) men. This difference remained after adjustment for the duration of T2DM, body mass index, and HbA1c level.
CONCLUSIONS: Older women have the highest risk of osteopenia and osteoporosis among patients with T2DM who have no history of fracture or osteoporosis treatment. These patients should undergo intensive monitoring for bone fragility from an early stage of their disease.
摘要：
目的：通过评估骨质量和数量，确定无骨折或骨质疏松治疗史的2型糖尿病（T2DM）患者存在骨并发症风险。
方法：在2021年至2022年期间到我们诊所就诊的门诊患者中，我们回顾性招募了137名（男性/女性：85/52，中位年龄：65岁）年龄≥40岁的T2DM患者，但没有骨折或骨质疏松症治疗史。使用双能X线吸收法确定腰椎和股骨颈骨密度和小梁骨评分。使用logistic回归分析确定与骨疾病相关的独立因素。并计算比值比(ORs)。
结果：年龄和女性性别与骨疾病发展的高OR显著相关。老年（≥65岁）女性的骨并发症综合风险比年轻（<65岁）男性高近40倍。在调整T2DM持续时间后，这一差异仍然存在。身体质量指数,和HbA1c水平。
结论：在没有骨折或骨质疏松治疗史的T2DM患者中，老年女性骨量减少和骨质疏松的风险最高。这些患者应从疾病的早期阶段开始对骨骼脆性进行强化监测。
方法：在2021年至2022年期间到我们诊所就诊的门诊患者中，我们回顾性招募了137名（男性/女性：85/52，中位年龄：65岁）年龄≥40岁的T2DM患者，但没有骨折或骨质疏松症治疗史。使用双能X线吸收法确定腰椎和股骨颈骨密度和小梁骨评分。使用logistic回归分析确定与骨疾病相关的独立因素。并计算比值比(ORs)。
结果：年龄和女性性别与骨疾病发展的高OR显著相关。老年（≥65岁）女性的骨并发症综合风险比年轻（<65岁）男性高近40倍。在调整T2DM持续时间后，这一差异仍然存在。身体质量指数,和HbA1c水平。
结论：在没有骨折或骨质疏松治疗史的T2DM患者中，老年女性骨量减少和骨质疏松的风险最高。这些患者应从疾病的早期阶段开始对骨骼脆性进行强化监测。
