PDF(Pubmed)
Abstract：
BACKGROUND: Mantle cell lymphoma is a rare lymphoma of the gastrointestinal tract that may present as multiple lymphomatous polyposis. We report a case of lymphomatous polyposis with a review of the literature.
METHODS: A 56-year-old man of Black ethnicity and Ivorian nationality with no relevant past medical history, consulted for a sudden onset symptoms of gastrointestinal obstruction, which evolved over 2 days. Macroscopic examination revealed the presence of multiple polyploid formations of the colonic mucosa. Histology showed diffuse lymphomatous proliferation of submucosa consisting off small lymphoid cells with a hyperchromatic crenelated nucleus, suggesting lymphomatous polyposis. Immunohistochemical examination showed expression by the tumor cells of antibodies to CD20, CD5, Bcl2, and cyclin D1. They did not express antibodies to CD10 and CD23. The Ki67 proliferation index was 25%. We have thus retained the diagnosis of mantle cell lymphomatous polyposis.
CONCLUSIONS: Multiple lymphomatous polyposis is a rare entity characterized by the presence of numerous gastrointestinal polyploid lesions sometimes involving several segments of the gastrointestinal tract. Typical lymphoma presenting as lymphomatous polyposis is mantle cell lymphoma; although, other tumors may have this aspect.
METHODS: A 56-year-old man of Black ethnicity and Ivorian nationality with no relevant past medical history, consulted for a sudden onset symptoms of gastrointestinal obstruction, which evolved over 2 days. Macroscopic examination revealed the presence of multiple polyploid formations of the colonic mucosa. Histology showed diffuse lymphomatous proliferation of submucosa consisting off small lymphoid cells with a hyperchromatic crenelated nucleus, suggesting lymphomatous polyposis. Immunohistochemical examination showed expression by the tumor cells of antibodies to CD20, CD5, Bcl2, and cyclin D1. They did not express antibodies to CD10 and CD23. The Ki67 proliferation index was 25%. We have thus retained the diagnosis of mantle cell lymphomatous polyposis.
CONCLUSIONS: Multiple lymphomatous polyposis is a rare entity characterized by the presence of numerous gastrointestinal polyploid lesions sometimes involving several segments of the gastrointestinal tract. Typical lymphoma presenting as lymphomatous polyposis is mantle cell lymphoma; although, other tumors may have this aspect.
摘要：
背景：套细胞淋巴瘤是一种罕见的胃肠道淋巴瘤，可能表现为多发性淋巴瘤性息肉病。我们报告了一例淋巴瘤性息肉病，并对文献进行了回顾。
方法：一名56岁的黑人和科特迪瓦籍男子，无相关既往病史，因突然出现的胃肠道梗阻症状而咨询，进化了2天。宏观检查显示结肠粘膜存在多个多倍体形成。组织学显示粘膜下层弥漫性淋巴瘤增生，由小淋巴细胞组成，核呈深色，提示淋巴瘤性息肉病.免疫组织化学检查显示肿瘤细胞表达CD20，CD5，Bcl2和细胞周期蛋白D1的抗体。它们不表达针对CD10和CD23的抗体。Ki67增殖指数为25%。因此，我们保留了套细胞淋巴瘤性息肉病的诊断。
结论：多发性淋巴瘤性息肉病是一种罕见的实体，其特征是存在许多胃肠道多倍体病变，有时涉及胃肠道的多个部分。表现为淋巴瘤性息肉病的典型淋巴瘤是套细胞淋巴瘤；尽管，其他肿瘤可能有这个方面。
方法：一名56岁的黑人和科特迪瓦籍男子，无相关既往病史，因突然出现的胃肠道梗阻症状而咨询，进化了2天。宏观检查显示结肠粘膜存在多个多倍体形成。组织学显示粘膜下层弥漫性淋巴瘤增生，由小淋巴细胞组成，核呈深色，提示淋巴瘤性息肉病.免疫组织化学检查显示肿瘤细胞表达CD20，CD5，Bcl2和细胞周期蛋白D1的抗体。它们不表达针对CD10和CD23的抗体。Ki67增殖指数为25%。因此，我们保留了套细胞淋巴瘤性息肉病的诊断。
结论：多发性淋巴瘤性息肉病是一种罕见的实体，其特征是存在许多胃肠道多倍体病变，有时涉及胃肠道的多个部分。表现为淋巴瘤性息肉病的典型淋巴瘤是套细胞淋巴瘤；尽管，其他肿瘤可能有这个方面。
