PDF(Pubmed)
Abstract：
Single nucleotide polymorphisms (SNPs) account for significant genomic variability in microbes, including the highly diverse gastric pathogen Helicobacter pylori. However, data on the effects of specific SNPs in pathogen-host interactions are scarce. Recent functional studies unravelled how a serine/leucine polymorphism in serine protease HtrA affects the formation of proteolytically active trimers and modulates cleavage of host cell-to-cell junction proteins during infection. A similar serine/leucine mutation in the carbohydrate binding domain of the adhesin BabA controls binding of ABO blood group antigens, enabling binding of either only the short Lewis b/H antigens of blood group O or also the larger antigens of blood groups A and B. Here we summarize the functional importance of these two remarkable bacterial SNPs and their effect on the outcome of pathogen-host interactions.
摘要：
单核苷酸多态性（SNP）是微生物中显著的基因组变异性，包括高度多样化的胃病原体幽门螺杆菌。然而,关于特定SNP在病原体-宿主相互作用中的影响的数据很少。最近的功能研究揭示了丝氨酸蛋白酶HtrA中的丝氨酸/亮氨酸多态性如何影响蛋白水解活性三聚体的形成并调节感染期间宿主细胞间连接蛋白的裂解。粘附素BabA的碳水化合物结合域中类似的丝氨酸/亮氨酸突变控制ABO血型抗原的结合，仅使血型O的短Lewisb/H抗原或血型A和B的较大抗原结合。在这里，我们总结了这两个显着的细菌SNP的功能重要性及其对病原体-宿主相互作用结果的影响。
