Abstract：
The influence of epigenetic factors on plant defense responses and the balance between growth and defense is becoming a central area in plant biology. It is believed that the biosynthesis of secondary metabolites can be regulated by epigenetic factors, but this is not associated with the formation of a \"memory\" to the previous biosynthetic status. This review shows that some epigenetic effects can result in epigenetic memory, which opens up new areas of research in secondary metabolites, in particular flavonoids. Plant-controlled chromatin modifications can lead to the generation of stress memory, a phenomenon through which information regarding past stress cues is retained, resulting in a modified response to recurring stress. How deeply are the mechanisms of chromatin modification and memory generation involved in the control of flavonoid biosynthesis? This article collects available information from the literature and interactome databases to address this issue. Visualization of the interaction of chromatin-modifying proteins with the flavonoid biosynthetic machinery is presented. Chromatin modifiers and \"bookmarks\" that may be involved in the regulation of flavonoid biosynthesis through memory have been identified. Through different mechanisms of chromatin modification, plants can harmonize flavonoid metabolism with: stress responses, developmental programs, light-dependent processes, flowering, and longevity programs. The available information points to the possibility of developing chromatin-modifying technologies to control flavonoid biosynthesis.
摘要：
表观遗传因素对植物防御反应的影响以及生长与防御之间的平衡正在成为植物生物学的核心领域。认为次生代谢产物的生物合成受表观遗传因素的调控,但这与先前生物合成状态的“记忆”的形成无关。这篇综述表明，一些表观遗传效应可以导致表观遗传记忆，这开辟了次生代谢物研究的新领域，特别是类黄酮。植物控制的染色质修饰可以导致压力记忆的产生，保留有关过去压力线索的信息的现象，导致对反复出现的压力的反应改变。染色质修饰和记忆生成的机制与黄酮类生物合成的控制有多深入？本文从文献和相互作用组数据库中收集了可用的信息来解决这个问题。提出了染色质修饰蛋白与类黄酮生物合成机制相互作用的可视化。已经确定了可能参与通过记忆调节类黄酮生物合成的染色质修饰剂和“书签”。通过不同的染色质修饰机制，植物可以协调类黄酮代谢与：应激反应，发展计划，依赖光的过程，开花,和长寿计划。现有信息表明开发染色质修饰技术以控制类黄酮生物合成的可能性。
