Abstract：
Cilia and Wnt signaling have a complex relationship, wherein Wnt regulates cilia and, conversely, cilia may affect Wnt signaling. Recently, it was shown that Wnt receptors are present in flagella, primary cilia, and multicilia, where they transmit an intraciliary signal that is independent of β-catenin. Intraciliary Wnt signaling promotes ciliogenesis, affecting male fertility, adipogenesis, and mucociliary clearance. Wnt also stimulates the beating of motile cilia, highlighting that these nanomotors, too, are chemosensory. Intraciliary Wnt signaling employs a Wnt-protein phosphatase 1 (PP1) signaling axis, involving the canonical Wnt pathway\'s inhibition of glycogen synthase kinase 3 (GSK3) to repress PP1 activity. Collectively, these findings support that cilia are Wnt signaling organelles, with implications for ciliopathies and cancer.
摘要：
纤毛和Wnt信号有复杂的关系，其中Wnt调节纤毛，相反,纤毛可能影响Wnt信号传导。最近,研究表明，Wnt受体存在于鞭毛中，初级纤毛,和多纤毛，其中它们传输独立于β-连环蛋白的纤内信号。纤毛内Wnt信号促进纤毛发生，影响男性生育能力，脂肪生成,和粘膜纤毛清除。Wnt还刺激能动纤毛的跳动，强调这些纳米马达，也是,是化学感官的。纤毛内Wnt信号采用Wnt蛋白磷酸酶1（PP1）信号轴，涉及经典Wnt途径抑制糖原合成酶激酶3（GSK3）抑制PP1活性。总的来说，这些发现支持纤毛是Wnt信号细胞器，与纤毛病变和癌症有关。
