Abstract：
Seven human donor eye globes underwent corneal cross-linking using theranostic UV-A device with accessory corneal iontophoresis system for patterned delivery of a 0.22% riboflavin solution. Theranostic-guided UV-A light illumination assessed riboflavin distribution and treated corneas at 10 mW/cm2 for 9 min with a 5.0-mm beam size. Corneal topography maps were taken at baseline and 2-h post-treatment. Analysis utilized corneal topography elevation data, with results showing controlled riboflavin delivery led to a consistent gradient, with 40% higher levels centrally (248 ± 79 μg/cm3) than peripherally (180 ± 72 μg/cm3 at ±2.5 mm from the center). Theranostic-guided UV-A light irradiation resulted in significant changes in corneal topography, with a decrease in best-fit sphere value (-0.7 ± 0.2 D; p < 0.001) and consistent downward shift in corneal elevation map (-11.7 ± 3.7 μm). The coefficient of variation was 2.5%, indicating high procedure performance in achieving significant and reliable corneal flattening.
摘要：
使用带有辅助角膜离子电渗系统的theranosticUV-A装置对七个人供体眼珠进行了角膜交联，以图案化递送0.22％的核黄素溶液。Theranostic引导的UV-A光照射评估了核黄素分布，并在10mW/cm2下以5.0mm的光束大小处理了9分钟的角膜。在基线和治疗后2小时采集角膜地形图。利用角膜地形图高程数据进行分析，结果表明，受控的核黄素递送导致一致的梯度，中心（248±79μg/cm3）比外围（距中心±2.5mm处180±72μg/cm3）高40％。Theranostic引导的UV-A光照射导致角膜地形图发生显著变化,最佳拟合球面值下降（-0.7±0.2D；p<0.001），角膜仰角图持续下移（-11.7±3.7μm）。变异系数为2.5%，表明在实现显著和可靠的角膜展平方面的高程序性能。
