Abstract：
BACKGROUND: The association between alcohol consumption and the risk of sudden cardiac death and/or fatal ventricular arrhythmia remains controversial.
OBJECTIVE: We analyzed the association between alcohol consumption, genetic traits for alcohol metabolism, and the risk of sudden cardiac death and/or fatal ventricular arrhythmia.
METHODS: We identified 397,164 individuals enrolled between 2006 and 2010 from the UK Biobank database and followed them until 2021. Alcohol consumption was categorized as current nondrinkers (nondrinkers and ex-drinkers), mild drinkers, moderate drinkers, or heavy drinkers. Genetic traits of alcohol metabolism were stratified according to the polygenic risk score tertiles. The primary and secondary outcomes were a composite of sudden cardiac death and fatal ventricular arrhythmia as well as their individual components.
RESULTS: During follow-up (median 12.5 years), 3543 cases (0.89%) of clinical outcomes occurred. Although mild, moderate, and heavy drinkers showed deceased risks of outcomes compared with current nondrinkers, there was no prognostic difference among nondrinkers, mild drinkers, moderate drinkers, and heavy drinkers. Ex-drinkers showed an increased risk in univariate analysis, but the significance was attenuated after adjusting covariates (hazard ratio 1.19; 95% confidence interval 0.94-1.50). As a continuous variable, alcohol consumption was not associated with clinical outcomes (hazard ratio 1.01; 95% confidence interval 0.99-1.02). Consistent with these findings, there was no association between genetic traits for alcohol metabolism and the risk of clinical outcomes.
CONCLUSIONS: Alcohol consumption was neither a protective factor nor a risk factor for sudden cardiac death or fatal ventricular arrhythmia. Genetic traits of alcohol metabolism were not associated with the clinical prognosis.
OBJECTIVE: We analyzed the association between alcohol consumption, genetic traits for alcohol metabolism, and the risk of sudden cardiac death and/or fatal ventricular arrhythmia.
METHODS: We identified 397,164 individuals enrolled between 2006 and 2010 from the UK Biobank database and followed them until 2021. Alcohol consumption was categorized as current nondrinkers (nondrinkers and ex-drinkers), mild drinkers, moderate drinkers, or heavy drinkers. Genetic traits of alcohol metabolism were stratified according to the polygenic risk score tertiles. The primary and secondary outcomes were a composite of sudden cardiac death and fatal ventricular arrhythmia as well as their individual components.
RESULTS: During follow-up (median 12.5 years), 3543 cases (0.89%) of clinical outcomes occurred. Although mild, moderate, and heavy drinkers showed deceased risks of outcomes compared with current nondrinkers, there was no prognostic difference among nondrinkers, mild drinkers, moderate drinkers, and heavy drinkers. Ex-drinkers showed an increased risk in univariate analysis, but the significance was attenuated after adjusting covariates (hazard ratio 1.19; 95% confidence interval 0.94-1.50). As a continuous variable, alcohol consumption was not associated with clinical outcomes (hazard ratio 1.01; 95% confidence interval 0.99-1.02). Consistent with these findings, there was no association between genetic traits for alcohol metabolism and the risk of clinical outcomes.
CONCLUSIONS: Alcohol consumption was neither a protective factor nor a risk factor for sudden cardiac death or fatal ventricular arrhythmia. Genetic traits of alcohol metabolism were not associated with the clinical prognosis.
摘要：
背景：饮酒与心源性猝死和/或致命性室性心律失常的风险之间的关系仍存在争议。
目的：我们分析了饮酒之间的关联，酒精代谢的遗传性状，以及心源性猝死和/或致命性室性心律失常的风险。
方法：我们从英国生物库数据库中确定了2006年至2010年之间注册的397,164名受试者，并随访至2021年。酒精消费被归类为当前不饮酒者（不饮酒者和前饮酒者），温和的饮酒者，适度饮酒者,或者酗酒者。根据多基因风险评分三元组对酒精代谢的遗传性状进行分层。主要和次要结果是心脏性猝死和致命性室性心律失常的复合结果，以及它们的各个组成部分。
结果：在随访期间（中位数为12.5年），3,543例发生临床结局。虽然温和，中度,与目前的不饮酒者相比，重度饮酒者显示出死亡的风险，不饮酒者之间没有预后差异，温和的饮酒者，适度饮酒者,酗酒者。在单因素分析中，前饮酒者显示出风险增加，但在调整协变量后,显著性减弱(风险比(HR)1.19;95%置信区间[CI]:0.94-1.50).作为连续变量，饮酒与临床结局无关(HR1.01;95%CI0.99-1.02).与这些发现一致，酒精代谢的遗传性状之间没有关联，和临床结果的风险。
结论：饮酒既不是心脏性猝死或致命性室性心律失常的保护因素，也不是危险因素。酒精代谢的遗传性状与临床预后无关。
目的：我们分析了饮酒之间的关联，酒精代谢的遗传性状，以及心源性猝死和/或致命性室性心律失常的风险。
方法：我们从英国生物库数据库中确定了2006年至2010年之间注册的397,164名受试者，并随访至2021年。酒精消费被归类为当前不饮酒者（不饮酒者和前饮酒者），温和的饮酒者，适度饮酒者,或者酗酒者。根据多基因风险评分三元组对酒精代谢的遗传性状进行分层。主要和次要结果是心脏性猝死和致命性室性心律失常的复合结果，以及它们的各个组成部分。
结果：在随访期间（中位数为12.5年），3,543例发生临床结局。虽然温和，中度,与目前的不饮酒者相比，重度饮酒者显示出死亡的风险，不饮酒者之间没有预后差异，温和的饮酒者，适度饮酒者,酗酒者。在单因素分析中，前饮酒者显示出风险增加，但在调整协变量后,显著性减弱(风险比(HR)1.19;95%置信区间[CI]:0.94-1.50).作为连续变量，饮酒与临床结局无关(HR1.01;95%CI0.99-1.02).与这些发现一致，酒精代谢的遗传性状之间没有关联，和临床结果的风险。
结论：饮酒既不是心脏性猝死或致命性室性心律失常的保护因素，也不是危险因素。酒精代谢的遗传性状与临床预后无关。
