Abstract：
Allergic rhinitis is a common allergic disease with a complex pathogenesis and many unresolved issues. Studies have shown that the incidence of allergic rhinitis is closely related to genetic factors, and research on the related genes could help further understand its pathogenesis and develop new treatment methods. In this study, 446 allergic rhinitis-related genes were obtained on the basis of the DisGeNET database. The protein-protein interaction network was searched using the random-walk-with-restart algorithm with these 446 genes as seed nodes to assess the linkages between other genes and allergic rhinitis. Then, this result was further examined by three screening tests, including permutation, interaction, and enrichment tests, which aimed to pick up genes that have strong and special associations with allergic rhinitis. 52 novel genes were finally obtained. The functional enrichment test confirmed their relationships to the biological processes and pathways related to allergic rhinitis. Furthermore, some genes were extensively analyzed to uncover their special or latent associations to allergic rhinitis, including IRAK2 and MAPK, which are involved in the pathogenesis of allergic rhinitis and the inhibition of allergic inflammation via the p38-MAPK pathway, respectively. The new found genes may help the following investigations for understanding the underlying molecular mechanisms of allergic rhinitis and developing effective treatments.
摘要：
变应性鼻炎是一种常见的变应性疾病,其发病机制复杂,存在许多尚未解决的问题。研究表明,变应性鼻炎的发病与遗传因素密切相关,相关基因的研究有助于进一步了解其发病机制，开发新的治疗方法。在这项研究中,基于DisGeNET数据库获得446个变应性鼻炎相关基因。以这些446个基因作为种子节点，使用随机行走-重启算法搜索蛋白质-蛋白质相互作用网络，以评估其他基因与过敏性鼻炎之间的联系。然后，通过三项筛查测试进一步检查了这一结果，包括排列，互动,和富集测试，其目的是提取与过敏性鼻炎有强烈和特殊关联的基因。最终获得了52个新基因。功能富集试验证实了它们与过敏性鼻炎相关的生物学过程和途径的关系。此外，对一些基因进行了广泛的分析，以揭示它们与过敏性鼻炎的特殊或潜在关联，包括IRAK2和MAPK，参与变应性鼻炎的发病和通过p38-MAPK通路抑制变应性炎症,分别。新发现的基因可能有助于以下研究，以了解过敏性鼻炎的潜在分子机制并开发有效的治疗方法。
