BRCA1 通过激活染色体异步检查点以消除重组缺陷的卵母细胞来保护基因组完整性。
关键词: chromosome asynapsis homologous recombination meiosis oocyte
Mesh : Oocytes / metabolism Animals BRCA1 Protein / genetics metabolism Female Mice Cell Cycle Proteins / metabolism genetics Mice, Knockout Meiosis / genetics Ataxia Telangiectasia Mutated Proteins / genetics metabolism deficiency DNA Breaks, Double-Stranded Chromosome Pairing / genetics Endodeoxyribonucleases / metabolism genetics Checkpoint Kinase 2 / genetics metabolism Phosphate-Binding Proteins / metabolism genetics Recombination, Genetic Homologous Recombination Genomic Instability
来 源:
DOI:10.1073/pnas.2401386121
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