UNASSIGNED: The cross-sectional survey based on real-world clinical consultations was conducted in the USA and five European countries. Obstetrician-gynecologists, primary-care physicians and oncologists provided demographic and symptom data for patients experiencing VMS; patients optionally self-reported their experiences via questionnaires, including their symptom profile and work/activity burden through the Menopause Quality of Life (MENQOL) and Work Productivity and Activity Impairment (WPAI) tools.
UNASSIGNED: Physicians completed survey forms on 2451 consulting patients; patients completed 1029 questionnaires. nVMS and iVMS severity was significantly associated with the severity of mood symptoms and sleep disturbances (p < 0.0001). However, around half of the patients with mild nVMS/iVMS also experienced moderate-severe mood changes (55.4%/43.7%) or sleep disturbances (42.4%/40.4%). Presence of mood/sleep disturbances alongside nVMS increased MENQOL vasomotor scores (p = 0.004/p < 0.001). Presence of sleep disturbances increased WPAI activity impairment (p < 0.001) but mood changes did not. Similar findings were reported for iVMS patients.
UNASSIGNED: Significant burden from the triad of natural or induced menopausal symptoms, sleep disturbances and mood changes affected women\'s daily activities, work and quality of life more than vasomotor symptoms alone.
■基于真实世界临床咨询的横断面调查在美国和五个欧洲国家进行。妇产科医生,初级保健医生和肿瘤学家为经历VMS的患者提供人口统计学和症状数据;患者任选地通过问卷自我报告他们的经历,通过更年期生活质量(MENQOL)和工作生产力和活动障碍(WPAI)工具,包括他们的症状概况和工作/活动负担。
■医师填写了2451名咨询患者的调查表;患者填写了1029份问卷。nVMS和iVMS严重程度与情绪症状和睡眠障碍的严重程度显着相关(p<0.0001)。然而,约一半的轻度nVMS/iVMS患者也经历了中重度情绪变化(55.4%/43.7%)或睡眠障碍(42.4%/40.4%).情绪/睡眠障碍和nVMS的存在增加了MENQOL血管舒缩评分(p=0.004/p<0.001)。睡眠障碍的存在增加了WPAI活动障碍(p<0.001),但情绪变化没有。iVMS患者也有类似的发现。
■自然或诱发的更年期症状三联征带来的重大负担,睡眠障碍和情绪变化影响女性的日常活动,工作和生活质量不仅仅是血管舒缩症状。