Abstract：
UNASSIGNED: This study aimed to examine physicians\' and patients\' perceptions regarding symptom burden and impact in women experiencing natural vasomotor symptoms (nVMS) or vasomotor symptoms induced by endocrine therapy for breast cancer (iVMS).
UNASSIGNED: The cross-sectional survey based on real-world clinical consultations was conducted in the USA and five European countries. Obstetrician-gynecologists, primary-care physicians and oncologists provided demographic and symptom data for patients experiencing VMS; patients optionally self-reported their experiences via questionnaires, including their symptom profile and work/activity burden through the Menopause Quality of Life (MENQOL) and Work Productivity and Activity Impairment (WPAI) tools.
UNASSIGNED: Physicians completed survey forms on 2451 consulting patients; patients completed 1029 questionnaires. nVMS and iVMS severity was significantly associated with the severity of mood symptoms and sleep disturbances (p < 0.0001). However, around half of the patients with mild nVMS/iVMS also experienced moderate-severe mood changes (55.4%/43.7%) or sleep disturbances (42.4%/40.4%). Presence of mood/sleep disturbances alongside nVMS increased MENQOL vasomotor scores (p = 0.004/p < 0.001). Presence of sleep disturbances increased WPAI activity impairment (p < 0.001) but mood changes did not. Similar findings were reported for iVMS patients.
UNASSIGNED: Significant burden from the triad of natural or induced menopausal symptoms, sleep disturbances and mood changes affected women\'s daily activities, work and quality of life more than vasomotor symptoms alone.
UNASSIGNED: The cross-sectional survey based on real-world clinical consultations was conducted in the USA and five European countries. Obstetrician-gynecologists, primary-care physicians and oncologists provided demographic and symptom data for patients experiencing VMS; patients optionally self-reported their experiences via questionnaires, including their symptom profile and work/activity burden through the Menopause Quality of Life (MENQOL) and Work Productivity and Activity Impairment (WPAI) tools.
UNASSIGNED: Physicians completed survey forms on 2451 consulting patients; patients completed 1029 questionnaires. nVMS and iVMS severity was significantly associated with the severity of mood symptoms and sleep disturbances (p < 0.0001). However, around half of the patients with mild nVMS/iVMS also experienced moderate-severe mood changes (55.4%/43.7%) or sleep disturbances (42.4%/40.4%). Presence of mood/sleep disturbances alongside nVMS increased MENQOL vasomotor scores (p = 0.004/p < 0.001). Presence of sleep disturbances increased WPAI activity impairment (p < 0.001) but mood changes did not. Similar findings were reported for iVMS patients.
UNASSIGNED: Significant burden from the triad of natural or induced menopausal symptoms, sleep disturbances and mood changes affected women\'s daily activities, work and quality of life more than vasomotor symptoms alone.
摘要：
■本研究旨在检查医师和患者对经历自然血管舒缩症状（nVMS）或内分泌治疗乳腺癌（iVMS）引起的血管舒缩症状的女性的症状负担和影响的看法。
■基于真实世界临床咨询的横断面调查在美国和五个欧洲国家进行。妇产科医生,初级保健医生和肿瘤学家为经历VMS的患者提供人口统计学和症状数据；患者任选地通过问卷自我报告他们的经历，通过更年期生活质量（MENQOL）和工作生产力和活动障碍（WPAI）工具，包括他们的症状概况和工作/活动负担。
■医师填写了2451名咨询患者的调查表；患者填写了1029份问卷。nVMS和iVMS严重程度与情绪症状和睡眠障碍的严重程度显着相关（p<0.0001）。然而,约一半的轻度nVMS/iVMS患者也经历了中重度情绪变化(55.4%/43.7%)或睡眠障碍(42.4%/40.4%).情绪/睡眠障碍和nVMS的存在增加了MENQOL血管舒缩评分(p=0.004/p<0.001)。睡眠障碍的存在增加了WPAI活动障碍（p<0.001），但情绪变化没有。iVMS患者也有类似的发现。
■自然或诱发的更年期症状三联征带来的重大负担，睡眠障碍和情绪变化影响女性的日常活动，工作和生活质量不仅仅是血管舒缩症状。
■基于真实世界临床咨询的横断面调查在美国和五个欧洲国家进行。妇产科医生,初级保健医生和肿瘤学家为经历VMS的患者提供人口统计学和症状数据；患者任选地通过问卷自我报告他们的经历，通过更年期生活质量（MENQOL）和工作生产力和活动障碍（WPAI）工具，包括他们的症状概况和工作/活动负担。
■医师填写了2451名咨询患者的调查表；患者填写了1029份问卷。nVMS和iVMS严重程度与情绪症状和睡眠障碍的严重程度显着相关（p<0.0001）。然而,约一半的轻度nVMS/iVMS患者也经历了中重度情绪变化(55.4%/43.7%)或睡眠障碍(42.4%/40.4%).情绪/睡眠障碍和nVMS的存在增加了MENQOL血管舒缩评分(p=0.004/p<0.001)。睡眠障碍的存在增加了WPAI活动障碍（p<0.001），但情绪变化没有。iVMS患者也有类似的发现。
■自然或诱发的更年期症状三联征带来的重大负担，睡眠障碍和情绪变化影响女性的日常活动，工作和生活质量不仅仅是血管舒缩症状。
