关键词: clarithromycin leprosy minocycline ofloxacin

Mesh : Humans Leprostatic Agents / therapeutic use Leprosy, Lepromatous / drug therapy Drug Therapy, Combination Male Leprosy, Borderline / drug therapy World Health Organization Quality of Life Adult

来  源:   DOI:10.1093/trstmh/trae027

Abstract:
Just as we prioritize personalized medicine for various other medical conditions, we should also include a neglected disease like leprosy, ensuring that patients receive the best care possible and improving their quality of life. Our case highlights the importance of instituting an alternate therapeutic regimen in a scenario where there is a lack of clinical response to multidrug therapy, even in the absence of documented drug resistance of the currently available molecular diagnostics. The search for the perfect regimen tailored for each individual leprosy patient should continue. Alternate anti-leprosy therapy is highly useful in cases with confirmed drug resistance or clinically non-responsive cases; however, their misuse should also be strictly avoided to prevent the development of resistance to them.
摘要:
正如我们为各种其他医疗状况优先考虑个性化医疗一样,我们还应该包括一种被忽视的疾病,比如麻风病,确保患者得到最好的护理,提高他们的生活质量。我们的案例强调了在对多药治疗缺乏临床反应的情况下建立替代治疗方案的重要性。即使在目前可用的分子诊断没有记录的耐药性的情况下。应继续寻找为每个麻风病患者量身定制的完美方案。替代抗麻风病治疗在已确认耐药性或临床无反应病例中非常有用;然而,还应严格避免滥用它们,以防止对它们的抵抗发展。
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