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Abstract：
Osteoarthritis (OA) is distinguished by pathological alterations in the synovial membrane, articular cartilage, and subchondral bone, resulting in physical symptoms such as pain, deformity, and impaired mobility. Numerous research studies have validated the effectiveness of low-intensity pulsed ultrasound (LIPUS) in OA treatment. The periodic mechanical waves generated by LIPUS can mitigate cellular ischemia and hypoxia, induce vibration and collision, produce notable thermal and non-thermal effects, alter cellular metabolism, expedite tissue repair, improve nutrient delivery, and accelerate the healing process of damaged tissues. The efficacy and specific mechanism of LIPUS is currently under investigation. This review provides an overview of LIPUS\'s potential role in the treatment of OA, considering various perspectives such as the synovial membrane, cartilage, subchondral bone, and tissue engineering. It aims to facilitate interdisciplinary scientific research and further exploration of LIPUS as a complementary technique to existing methods or surgery. Ongoing research is focused on determining the optimal dosage, frequency, timing, and treatment strategy of LIPUS for OA. Additional research is required to clarify the precise mechanism of action and potential impacts on cellular, animal, and human systems prior to its integration into therapeutic applications.
摘要：
骨关节炎（OA）的特点是滑膜的病理改变，关节软骨,和软骨下骨，导致身体症状，如疼痛，畸形,和行动不便。许多研究已经验证了低强度脉冲超声（LIPUS）在OA治疗中的有效性。LIPUS产生的周期性机械波可以减轻细胞缺血和缺氧，引起振动和碰撞，产生显著的热效应和非热效应，改变细胞代谢，加快组织修复，改善营养输送，加速受损组织的愈合过程。目前正在研究LIPUS的疗效和具体机制。本文综述了LIPUS在OA治疗中的潜在作用。考虑到各种观点，如滑膜，软骨，软骨下骨,和组织工程。它旨在促进跨学科科学研究和进一步探索LIPUS作为现有方法或手术的补充技术。正在进行的研究集中在确定最佳剂量上，频率,定时,和LIPUS治疗OA的策略。需要额外的研究来阐明作用的确切机制和对细胞的潜在影响，动物,和人类系统之前，其集成到治疗应用。
