PDF(Pubmed)
Abstract：
Prevalent neurological disorders such as Alzheimer\'s disease, Parkinson\'s disease, and stroke are increasingly becoming a global burden as society ages. It is well-known that degeneration and loss of neurons are the fundamental underlying processes, but there are still no effective therapies for these neurological diseases. In recent years, plenty of studies have focused on the pharmacology and feasibility of natural products as new strategies for the development of drugs that target neurological disorders. Antrodia camphorata has become one of the most promising candidates, and the crude extracts and some active metabolites of it have been reported to play various pharmacological activities to alleviate neurological symptoms at cellular and molecular levels. This review highlights the current evidence of Antrodia camphorata against neurological disorders, including safety evaluation, metabolism, blood-brain barrier penetration, neuroprotective activities, and the potential on regulating the gut-microbiome-brain axis. Furthermore, potential strategies to resolve problematic issues identified in previous studies are also discussed. We aim to provide an overview for the ongoing development and utilization of Antrodia camphorata in cerebral neuropathology.
摘要：
普遍的神经系统疾病，如阿尔茨海默病，帕金森病,随着社会年龄的增长，中风越来越成为全球负担。众所周知，神经元的变性和丢失是基本的基础过程，但是这些神经系统疾病仍然没有有效的治疗方法。近年来,大量的研究集中在天然产物的药理学和可行性，作为开发针对神经系统疾病的药物的新策略。牛樟芝已成为最有前途的候选人之一，据报道，其粗提物和一些活性代谢产物在细胞和分子水平上发挥各种药理活性，缓解神经系统症状。这篇综述强调了樟芝对抗神经系统疾病的当前证据，包括安全评估，新陈代谢，血脑屏障穿透，神经保护活动，以及调节肠道-微生物组-大脑轴的潜力。此外，还讨论了解决先前研究中发现的问题的潜在策略。我们旨在为樟芝在脑神经病理学中的持续开发和利用提供概述。
