PDF(Pubmed)
Abstract：
Bone marrow failure (BMF) has become one of the most studied autoimmune disorders, particularly due to its prevalence both as an inherited disease, but also as a result of chemotherapies. BMF is associated with severe symptoms such as bleeding episodes and susceptibility to infections, and often has underlying characteristics, such as anemia, thrombocytopenia, and neutropenia. The current treatment landscape for BMF requires stem cell transplantation or chemotherapies to induce immune suppression. However, there is limited donor cell availability or dose related toxicity associated with these treatments. Optimizing these treatments has become a necessity. Polymer-based materials have become increasingly popular, as current research efforts are focused on synthesizing novel cell matrices for stem cell expansion to solve limited donor cell availability, as well as applying polymer delivery vehicles to intracellularly deliver cargo that can aid in immunosuppression. Here, we discuss the importance and impact of polymer materials to enhance therapeutics in the context of BMF.
摘要：
骨髓衰竭（BMF）已成为研究最多的自身免疫性疾病之一，特别是由于它作为一种遗传性疾病的流行，也是化疗的结果。BMF与严重症状相关，如出血发作和感染易感性，并且通常具有潜在的特征，比如贫血,血小板减少症,和中性粒细胞减少症.目前BMF的治疗需要干细胞移植或化疗来诱导免疫抑制。然而,与这些治疗相关的供体细胞可用性或剂量相关的毒性有限.优化这些治疗已经成为一种需要。聚合物基材料越来越受欢迎，由于目前的研究工作集中在合成用于干细胞扩增的新型细胞基质，以解决有限的供体细胞可用性，以及应用聚合物递送载体以在胞内递送有助于免疫抑制的货物。这里,我们讨论了聚合物材料在BMF背景下增强治疗的重要性和影响。
