PDF(Pubmed)
Abstract：
UNASSIGNED: The blood-brain barrier (BBB) is a critical neurovascular unit regulating substances\' passage from the bloodstream to the brain. Its selective permeability poses significant challenges in drug delivery for neurological disorders. Conventional methods often fail due to the BBB\'s complex structure.
UNASSIGNED: The study aims to shed light on their pivotal role in revolutionizing neurotherapeutics and explores the transformative potential of BBB-on-a-Chip technologies in drug delivery research to comprehensively review BBB-on-a-chip technologies, focusing on their design, and substantiate advantages over traditional models.
UNASSIGNED: A detailed analysis of existing literature and experimental data pertaining to BBB-on-a-Chip technologies was conducted. Various models, their physiological relevance, and innovative design considerations were examined through databases like Scopus, EbscoHost, PubMed Central, and Medline. Case studies demonstrating enhanced drug transport through BBB-on-a-Chip models were also reviewed, highlighting their potential impact on neurological disorders.
UNASSIGNED: BBB-on-a-Chip models offer a revolutionary approach, accurately replicating BBB properties. These microphysiological systems enable high-throughput screening, real-time monitoring of drug transport, and precise localization of drugs. Case studies demonstrate their efficacy in enhancing drug penetration, offering potential therapies for diseases like Parkinson\'s and Alzheimer\'s.
UNASSIGNED: BBB-on-a-Chip models represent a transformative milestone in drug delivery research. Their ability to replicate BBB complexities, offer real-time monitoring, and enhance drug transport holds immense promise for neurological disorders. Continuous research and development are imperative to unlock BBB-on-a-Chip models\' full potential, ushering in a new era of targeted, efficient, and safer drug therapies for challenging neurological conditions.
UNASSIGNED: The study aims to shed light on their pivotal role in revolutionizing neurotherapeutics and explores the transformative potential of BBB-on-a-Chip technologies in drug delivery research to comprehensively review BBB-on-a-chip technologies, focusing on their design, and substantiate advantages over traditional models.
UNASSIGNED: A detailed analysis of existing literature and experimental data pertaining to BBB-on-a-Chip technologies was conducted. Various models, their physiological relevance, and innovative design considerations were examined through databases like Scopus, EbscoHost, PubMed Central, and Medline. Case studies demonstrating enhanced drug transport through BBB-on-a-Chip models were also reviewed, highlighting their potential impact on neurological disorders.
UNASSIGNED: BBB-on-a-Chip models offer a revolutionary approach, accurately replicating BBB properties. These microphysiological systems enable high-throughput screening, real-time monitoring of drug transport, and precise localization of drugs. Case studies demonstrate their efficacy in enhancing drug penetration, offering potential therapies for diseases like Parkinson\'s and Alzheimer\'s.
UNASSIGNED: BBB-on-a-Chip models represent a transformative milestone in drug delivery research. Their ability to replicate BBB complexities, offer real-time monitoring, and enhance drug transport holds immense promise for neurological disorders. Continuous research and development are imperative to unlock BBB-on-a-Chip models\' full potential, ushering in a new era of targeted, efficient, and safer drug therapies for challenging neurological conditions.
摘要：
■血脑屏障（BBB）是调节物质从血流到大脑的关键神经血管单元。其选择性渗透性在用于神经障碍的药物递送中提出了重大挑战。由于BBB的复杂结构，常规方法通常会失败。
■该研究旨在阐明其在彻底改变神经疗法中的关键作用，并探索BBB-on-a-chip技术在药物递送研究中的变革潜力，以全面审查BBB-a-chip技术，专注于他们的设计，并证实了相对于传统模式的优势。
■对与芯片上BBB技术有关的现有文献和实验数据进行了详细分析。各种型号，它们的生理相关性，通过Scopus等数据库检查了创新设计考虑因素，EbscoHost,PubMedCentral,Medline还审查了证明通过BBB-on-a-Chip模型增强药物转运的案例研究，强调它们对神经系统疾病的潜在影响。
■BBB-on-a-Chip模型提供了一种革命性的方法，准确复制BBB特性。这些微生理系统能够实现高通量筛选，药物运输的实时监控，和药物的精确定位。案例研究证明了它们在增强药物渗透方面的功效，为帕金森氏症和阿尔茨海默氏症等疾病提供潜在的治疗方法。
■BBB-on-a-chip模型代表了药物递送研究的一个变革性里程碑。它们复制BBB复杂性的能力，提供实时监控，增强药物运输对神经系统疾病有着巨大的希望。持续的研究和开发是必要的，以释放BBB芯片模型的全部潜力，开创了一个有针对性的新时代，高效,和更安全的药物治疗具有挑战性的神经系统疾病。
■该研究旨在阐明其在彻底改变神经疗法中的关键作用，并探索BBB-on-a-chip技术在药物递送研究中的变革潜力，以全面审查BBB-a-chip技术，专注于他们的设计，并证实了相对于传统模式的优势。
■对与芯片上BBB技术有关的现有文献和实验数据进行了详细分析。各种型号，它们的生理相关性，通过Scopus等数据库检查了创新设计考虑因素，EbscoHost,PubMedCentral,Medline还审查了证明通过BBB-on-a-Chip模型增强药物转运的案例研究，强调它们对神经系统疾病的潜在影响。
■BBB-on-a-Chip模型提供了一种革命性的方法，准确复制BBB特性。这些微生理系统能够实现高通量筛选，药物运输的实时监控，和药物的精确定位。案例研究证明了它们在增强药物渗透方面的功效，为帕金森氏症和阿尔茨海默氏症等疾病提供潜在的治疗方法。
■BBB-on-a-chip模型代表了药物递送研究的一个变革性里程碑。它们复制BBB复杂性的能力，提供实时监控，增强药物运输对神经系统疾病有着巨大的希望。持续的研究和开发是必要的，以释放BBB芯片模型的全部潜力，开创了一个有针对性的新时代，高效,和更安全的药物治疗具有挑战性的神经系统疾病。
