PDF(Pubmed)
Abstract：
UNASSIGNED: Severe hypertriglyceridemia (HTG), defined as plasma triglyceride (TG) concentration > 10 mmol/L, is relatively uncommon, and its implications for atherosclerotic cardiovascular disease (ASCVD) risk remain somewhat unclear. We evaluated the association between severe HTG and carotid intima-media thickness (IMT), a marker for ASCVD.
UNASSIGNED: We studied three clinical cohorts: 88 patients with severe HTG (mean TG level 20.6 mmol/L), 271 patients with familial hypercholesterolemia (FH) as a contrast group, and 70 normolipidemic controls. Carotid IMT was measured using standardized ultrasound imaging. Statistical analysis was conducted using one-way analysis of variance (ANOVA) to compare mean IMT values, analysis of covariance (ANCOVA) to adjust for confounding variables, specifically age and sex, as well as Spearman pairwise correlation analysis between variables.
UNASSIGNED: Unadjusted mean carotid IMT was greater in severe HTG and FH groups compared to controls, however, this was no longer significant for severe HTG after adjustment for age and sex. In contrast, adjusted carotid IMT remained significantly different between the FH and control groups.
UNASSIGNED: Our findings suggest that extreme TG elevations in severe HTG patients are not significantly associated with carotid IMT, in contrast to the increased IMT seen in FH patients. These findings add perspective to the complex relationship between severe HTG and ASCVD risk.
UNASSIGNED: We studied three clinical cohorts: 88 patients with severe HTG (mean TG level 20.6 mmol/L), 271 patients with familial hypercholesterolemia (FH) as a contrast group, and 70 normolipidemic controls. Carotid IMT was measured using standardized ultrasound imaging. Statistical analysis was conducted using one-way analysis of variance (ANOVA) to compare mean IMT values, analysis of covariance (ANCOVA) to adjust for confounding variables, specifically age and sex, as well as Spearman pairwise correlation analysis between variables.
UNASSIGNED: Unadjusted mean carotid IMT was greater in severe HTG and FH groups compared to controls, however, this was no longer significant for severe HTG after adjustment for age and sex. In contrast, adjusted carotid IMT remained significantly different between the FH and control groups.
UNASSIGNED: Our findings suggest that extreme TG elevations in severe HTG patients are not significantly associated with carotid IMT, in contrast to the increased IMT seen in FH patients. These findings add perspective to the complex relationship between severe HTG and ASCVD risk.
摘要：
■严重的高甘油三酯血症（HTG），定义为血浆甘油三酯（TG）浓度>10mmol/L，相对不常见，其对动脉粥样硬化性心血管疾病(ASCVD)风险的影响尚不清楚.我们评估了重度HTG与颈动脉内中膜厚度（IMT）之间的关系，ASCVD的标记。
■我们研究了三个临床队列：88例重度HTG患者（平均TG水平20.6mmol/L），271例家族性高胆固醇血症（FH）患者作为对比组，和70名血脂正常对照。使用标准化超声成像测量颈动脉IMT。使用单向方差分析(ANOVA)进行统计学分析以比较平均IMT值,协方差分析(ANCOVA)以调整混杂变量，特别是年龄和性别，以及变量之间的Spearman成对相关分析。
■重度HTG和FH组未调整平均颈动脉IMT高于对照组，然而,在校正了年龄和性别后,这对重度HTG不再显著.相比之下,调整后的颈动脉IMT在FH组和对照组之间仍然存在显着差异。
■我们的研究结果表明，重度HTG患者的TG升高与颈动脉IMT无显著相关性，与FH患者的IMT增加相反。这些发现为严重的HTG和ASCVD风险之间的复杂关系增加了视角。
■我们研究了三个临床队列：88例重度HTG患者（平均TG水平20.6mmol/L），271例家族性高胆固醇血症（FH）患者作为对比组，和70名血脂正常对照。使用标准化超声成像测量颈动脉IMT。使用单向方差分析(ANOVA)进行统计学分析以比较平均IMT值,协方差分析(ANCOVA)以调整混杂变量，特别是年龄和性别，以及变量之间的Spearman成对相关分析。
■重度HTG和FH组未调整平均颈动脉IMT高于对照组，然而,在校正了年龄和性别后,这对重度HTG不再显著.相比之下,调整后的颈动脉IMT在FH组和对照组之间仍然存在显着差异。
■我们的研究结果表明，重度HTG患者的TG升高与颈动脉IMT无显著相关性，与FH患者的IMT增加相反。这些发现为严重的HTG和ASCVD风险之间的复杂关系增加了视角。
