Abstract：
OBJECTIVE: To investigate the features of the anterior segment structures in neovascular glaucoma (NVG) and analyze its differences from primary angle-closure glaucoma (PACG).
METHODS: This study included patients who were first diagnosed with monocular NVG and PACG at the Affiliated Eye Hospital of Nanchang University during August 2019 to June 2022. Ultrasound biomicroscopy (UBM) was used to measure the anterior segment parameters of those eyes, including anterior chamber depth (ACD), anterior chamber width (ACW), anterior chamber area (ACA), iris area (IA), maximum iris thickness (ITMAX), middle iris thickness (ITMID), iris curvature (IC), lens vault (LV), angle opening distance (AOD500), trabecular iris angle (TIA500), trabecular-iris space area (TISA500) and peripheral anterior synechia (PAS) length.
RESULTS: In this study, paired samples t-test showed that IA [1.170(0.324) mm2], ITMAX [0.368(0.079) mm], ITMID [0.280(0.062) mm] and IC [0.147(0.037) mm] of NVG were smaller than F-NVG [2.058(0.195) mm2, 0.611(0.045) mm, 0.415(0.049) mm and 0.272(0.077) mm], the AOD500, TIA500, and TISA500 of NVG were also smaller than F-NVG. Independent samples t-test showed that ACD [2.349(0.350) mm] and ACA [16.326(3.547) mm2] of NVG were larger than PACG [1.971(0.240) mm, 12.030(1.860) mm2], but the IA [1.170(0.324) mm2], ITMAX [0.368(0.079) mm], ITMID [0.280(0.062) mm], IC [0.147(0.037) mm] and LV [0.436(0.172 mm)] were smaller than PACG [1.740(0.294) mm2, 0.548(0.084) mm, 0.404(0.065) mm, 0.283(0.060) mm and 0.737(0.196) mm]. Among the 16 patients with 360° angle-closure NVG, the PAS length was 0.834 (0.326) mm, which exceeded the Schwalbe line.
CONCLUSIONS: In NVG, the iris is atrophied, thinned, and straight, while the ACD is normal or slightly shallow. In 360° angle-closure NVG, the PAS length exceeds the Schwalbe line, presenting a pseudo angle phenomenon and a hockey stick sign. Notably, the anterior segment structure morphology of NVG exhibit differences from those of PACG.
METHODS: This study included patients who were first diagnosed with monocular NVG and PACG at the Affiliated Eye Hospital of Nanchang University during August 2019 to June 2022. Ultrasound biomicroscopy (UBM) was used to measure the anterior segment parameters of those eyes, including anterior chamber depth (ACD), anterior chamber width (ACW), anterior chamber area (ACA), iris area (IA), maximum iris thickness (ITMAX), middle iris thickness (ITMID), iris curvature (IC), lens vault (LV), angle opening distance (AOD500), trabecular iris angle (TIA500), trabecular-iris space area (TISA500) and peripheral anterior synechia (PAS) length.
RESULTS: In this study, paired samples t-test showed that IA [1.170(0.324) mm2], ITMAX [0.368(0.079) mm], ITMID [0.280(0.062) mm] and IC [0.147(0.037) mm] of NVG were smaller than F-NVG [2.058(0.195) mm2, 0.611(0.045) mm, 0.415(0.049) mm and 0.272(0.077) mm], the AOD500, TIA500, and TISA500 of NVG were also smaller than F-NVG. Independent samples t-test showed that ACD [2.349(0.350) mm] and ACA [16.326(3.547) mm2] of NVG were larger than PACG [1.971(0.240) mm, 12.030(1.860) mm2], but the IA [1.170(0.324) mm2], ITMAX [0.368(0.079) mm], ITMID [0.280(0.062) mm], IC [0.147(0.037) mm] and LV [0.436(0.172 mm)] were smaller than PACG [1.740(0.294) mm2, 0.548(0.084) mm, 0.404(0.065) mm, 0.283(0.060) mm and 0.737(0.196) mm]. Among the 16 patients with 360° angle-closure NVG, the PAS length was 0.834 (0.326) mm, which exceeded the Schwalbe line.
CONCLUSIONS: In NVG, the iris is atrophied, thinned, and straight, while the ACD is normal or slightly shallow. In 360° angle-closure NVG, the PAS length exceeds the Schwalbe line, presenting a pseudo angle phenomenon and a hockey stick sign. Notably, the anterior segment structure morphology of NVG exhibit differences from those of PACG.
摘要：
目的：探讨新生血管性青光眼（NVG）眼前节结构的特点，并分析其与原发性闭角型青光眼（PACG）的差异。
方法：本研究纳入南昌大学附属眼科医院2019年8月至2022年6月首次诊断为单眼NVG和PACG的患者。超声生物显微镜（UBM）用于测量这些眼睛的眼前节参数，包括前房深度（ACD），前房宽度（ACW），前房面积（ACA），虹膜面积(IA),最大虹膜厚度(ITMAX),虹膜中间厚度（ITMID），虹膜曲率（IC），镜头拱顶（LV），角开距离(AOD500),小梁虹膜角度（TIA500），小梁-虹膜间隙面积（TISA500）和周围前粘连（PAS）长度。
结果：在这项研究中，配对样本t检验显示IA[1.170(0.324)mm2]，ITMAX[0.368(0.079)mm],NVG的ITMID[0.280(0.062)mm]和IC[0.147(0.037)mm]小于F-NVG[2.058(0.195)mm2,0.611(0.045)mm,0.415(0.049)mm和0.272(0.077)mm],NVG的AOD500、TIA500和TISA500也小于F-NVG。独立样本t检验表明，NVG的ACD[2.349（0.350）mm]和ACA[16.326（3.547）mm2]大于PACG[1.971（0.240）mm，12.030(1.860)mm2],但IA[1.170(0.324)mm2]，ITMAX[0.368(0.079)mm],ITMID[0.280(0.062)mm],IC[0.147(0.037)mm]和LV[0.436(0.172mm)]小于PACG[1.740(0.294)mm2,0.548(0.084)mm,0.404(0.065)mm,0.283(0.060)mm和0.737(0.196)mm]。在16例360°闭角NVG患者中，PAS长度为0.834（0.326）mm，超过了Schwalbe线.
结论：在NVG中，虹膜萎缩了,变薄，和直,而ACD正常或稍浅。在360°闭角NVG中，PAS长度超过Schwalbe线，呈现伪角度现象和曲棍球棒标志。值得注意的是,NVG的眼前节结构形态与PACG不同。
方法：本研究纳入南昌大学附属眼科医院2019年8月至2022年6月首次诊断为单眼NVG和PACG的患者。超声生物显微镜（UBM）用于测量这些眼睛的眼前节参数，包括前房深度（ACD），前房宽度（ACW），前房面积（ACA），虹膜面积(IA),最大虹膜厚度(ITMAX),虹膜中间厚度（ITMID），虹膜曲率（IC），镜头拱顶（LV），角开距离(AOD500),小梁虹膜角度（TIA500），小梁-虹膜间隙面积（TISA500）和周围前粘连（PAS）长度。
结果：在这项研究中，配对样本t检验显示IA[1.170(0.324)mm2]，ITMAX[0.368(0.079)mm],NVG的ITMID[0.280(0.062)mm]和IC[0.147(0.037)mm]小于F-NVG[2.058(0.195)mm2,0.611(0.045)mm,0.415(0.049)mm和0.272(0.077)mm],NVG的AOD500、TIA500和TISA500也小于F-NVG。独立样本t检验表明，NVG的ACD[2.349（0.350）mm]和ACA[16.326（3.547）mm2]大于PACG[1.971（0.240）mm，12.030(1.860)mm2],但IA[1.170(0.324)mm2]，ITMAX[0.368(0.079)mm],ITMID[0.280(0.062)mm],IC[0.147(0.037)mm]和LV[0.436(0.172mm)]小于PACG[1.740(0.294)mm2,0.548(0.084)mm,0.404(0.065)mm,0.283(0.060)mm和0.737(0.196)mm]。在16例360°闭角NVG患者中，PAS长度为0.834（0.326）mm，超过了Schwalbe线.
结论：在NVG中，虹膜萎缩了,变薄，和直,而ACD正常或稍浅。在360°闭角NVG中，PAS长度超过Schwalbe线，呈现伪角度现象和曲棍球棒标志。值得注意的是,NVG的眼前节结构形态与PACG不同。
