OBJECTIVE: We aimed to summarize the current literature regarding DaTSCAN findings in patients with rare neurodegenerative parkinsonisms.
METHODS: The PubMed database was systematically screened for studies in English or Spanish up to October 15, 2023, using search terms \"DaTSCAN\", \"ioflupane\", \"DaT-SPECT\", \"123I-FP-CIT SPECT\", \"dopamine transporter imaging\", and \"[123I] FP-CIT SPECT\". Duplicated publications and studies regarding PD, atypical parkinsonisms, dystonia-parkinsonism, essential tremor, and parkinsonism due to non-degenerative causes were excluded.
RESULTS: The obtained results were reviewed and summarized, including DaTSCAN findings in fragile X-associated tremor/ataxia syndrome, prion diseases, Huntington\'s disease, spinocerebellar ataxia, hereditary spastic paraparesis, metabolic disorders, and other diseases (anti-IgLON5 disease, ring chromosome 20 syndrome, chorea-acanthocytosis, and neuronal ceroid lipofuscinosis).
CONCLUSIONS: This review highlights the need to determine in the future the utility and cost-effectiveness of DaTSCAN, both as a diagnostic and a prognostic tool, in patients with parkinsonian symptoms in rare neurodegenerative diseases.
目的:我们旨在总结目前关于DaTSCAN在罕见神经退行性帕金森病患者中的发现的文献。
方法:截至2023年10月15日,使用搜索词“DaTSCAN”对PubMed数据库进行了系统的英语或西班牙语研究筛选,\"ioflupane\",\"DaT-SPECT\",“123I-FP-CITSPECT”,“多巴胺转运蛋白成像”,和“[123I]FP-CITSPECT”。关于PD的重复出版物和研究,非典型帕金森病,肌张力障碍-帕金森病,特发性震颤,排除由非退行性原因引起的帕金森病。
结果:对获得的结果进行了回顾和总结,包括DaTSCAN在脆性X相关震颤/共济失调综合征中的发现,朊病毒病,亨廷顿病,脊髓小脑共济失调,遗传性痉挛性轻瘫,代谢紊乱,和其他疾病(抗IgLON5疾病,环染色体20综合征,舞蹈病-棘皮细胞增多症,和神经元类脂褐菌病)。
结论:这篇综述强调了在未来确定DaTSCAN的效用和成本效益的必要性,作为诊断和预测工具,在罕见的神经退行性疾病中具有帕金森病症状的患者中。