Abstract：
OBJECTIVE: To analyze the clinicopathological and evolutionary profile of the main locations of oral squamous cell carcinoma (OSCC).
METHODS: This is a retrospective study on 133 patients treated for OSCC. The group was composed of 48 women and 85 men, with a mean age 63.9 ± 12.73 years. Most cases involved the lingual border of tongue (63), followed by the gingiva (36) and the floor of mouth (34). A comparative analysis was performed using multinomial regression.
RESULTS: There were significant differences regarding age, sex, tobacco and alcohol consumption, liver pathology, oral potentially malignant disorders, and bone and perineural invasion. In multivariate regression, tobacco consumption, and bone invasion remained significant. There were no significant differences in relation to prognosis.
CONCLUSIONS: The location of OSCC is an important factor in the clinicopathological assessment of this neoplasm. The main locations of OSCC show differential etiopathogenic and clinicopathological aspects. Tobacco consumption has a great relevance in the floor of mouth; nonetheless, it is less important in the tongue border and the gum, which suggests other pathogenic factors. It is necessary to consider the anatomical location of OSCC in preventive protocols, with the aim of reducing its high mortality.
METHODS: This is a retrospective study on 133 patients treated for OSCC. The group was composed of 48 women and 85 men, with a mean age 63.9 ± 12.73 years. Most cases involved the lingual border of tongue (63), followed by the gingiva (36) and the floor of mouth (34). A comparative analysis was performed using multinomial regression.
RESULTS: There were significant differences regarding age, sex, tobacco and alcohol consumption, liver pathology, oral potentially malignant disorders, and bone and perineural invasion. In multivariate regression, tobacco consumption, and bone invasion remained significant. There were no significant differences in relation to prognosis.
CONCLUSIONS: The location of OSCC is an important factor in the clinicopathological assessment of this neoplasm. The main locations of OSCC show differential etiopathogenic and clinicopathological aspects. Tobacco consumption has a great relevance in the floor of mouth; nonetheless, it is less important in the tongue border and the gum, which suggests other pathogenic factors. It is necessary to consider the anatomical location of OSCC in preventive protocols, with the aim of reducing its high mortality.
摘要：
目的：分析口腔鳞状细胞癌（OSCC）主要部位的临床病理特征和演化特征。
方法：这是一项针对133例OSCC患者的回顾性研究。该小组由48名女性和85名男性组成，平均年龄63.9±12.73岁。大多数病例涉及舌的舌边界（63），其次是牙龈（36）和口底（34）。使用多项回归进行比较分析。
结果：年龄存在显著差异，性别,烟草和酒精消费，肝脏病理学,口腔潜在恶性疾病，骨和神经周浸润。在多元回归中，烟草消费,骨侵入仍然显著。在预后方面没有显著差异。
结论：OSCC的位置是该肿瘤临床病理评估的重要因素。OSCC的主要位置显示出不同的病因和临床病理方面。烟草消费在口底有很大的相关性；尽管如此，它在舌头边界和牙龈上不那么重要，这表明其他致病因素。在预防方案中有必要考虑OSCC的解剖位置，目的是降低其高死亡率。
方法：这是一项针对133例OSCC患者的回顾性研究。该小组由48名女性和85名男性组成，平均年龄63.9±12.73岁。大多数病例涉及舌的舌边界（63），其次是牙龈（36）和口底（34）。使用多项回归进行比较分析。
结果：年龄存在显著差异，性别,烟草和酒精消费，肝脏病理学,口腔潜在恶性疾病，骨和神经周浸润。在多元回归中，烟草消费,骨侵入仍然显著。在预后方面没有显著差异。
结论：OSCC的位置是该肿瘤临床病理评估的重要因素。OSCC的主要位置显示出不同的病因和临床病理方面。烟草消费在口底有很大的相关性；尽管如此，它在舌头边界和牙龈上不那么重要，这表明其他致病因素。在预防方案中有必要考虑OSCC的解剖位置，目的是降低其高死亡率。
