Abstract：
The contamination of paper products by various chemicals has been reported on a global level, but to date, no published research has investigated pharmaceutical contamination of paper-based products. In this study, pharmaceutical analysis was conducted on 42 samples collected from various points of the recycled paper value chain in Cape Town, South Africa, which included the various grades that may be included in the manufacturing of recycled paperboard. The analysis was achieved by ultrasonic-assisted extraction of paper samples before detection by UHPLC-Q Orbitrap. Quantification limits ranged from 1.15 pg/g for ketoprofen to 46.07 pg/g for methocarbamol. Pharmaceuticals identified in newspaper samples were dexamethasone, ketoprofen, and 17β-estradiol. The latter was also detected in paper shopping bags (up to 697.49 ng/g), infant bathtub packaging (280.62 ng/g), battery packaging (137.43 ng/g), and an egg carton (170.47 ng/g). Carbamazepine was also prominent with its concentration reaching 13.02 ng/g in a vegetable box. Suspect screening tentatively identified 14 additional pharmaceuticals in paper samples, with minocycline, prazepam, and anabolic steroids appearing more prominently. This pioneering study indicated that unintentional pharmaceutical exposure had expanded beyond environmental media to consumer products.
摘要：
各种化学品对纸制品的污染在全球范围内已有报道,但迄今为止,没有发表的研究调查纸基产品的药物污染。在这项研究中,对从开普敦再生纸价值链各点收集的42个样品进行了药物分析，南非,其中包括制造回收纸板可能包括的各种等级。在通过UHPLC-QOrbitrap检测之前,通过纸样品的超声波辅助提取来实现分析。定量限值范围为酮洛芬的1.15pg/g至美托卡巴洛尔的46.07pg/g。报纸样本中鉴定的药物是地塞米松，酮洛芬,和17β-雌二醇。后者也在纸质购物袋(高达697.49纳克/克)中检测到，婴儿浴缸包装（280.62纳克/克），电池包装（137.43纳克/克），和一个鸡蛋盒（170.47纳克/克）。卡马西平也很突出，在蔬菜盒中的浓度达到13.02ng/g。可疑筛查初步确定了纸质样品中的14种其他药物，米诺环素,Prazepam,合成代谢类固醇更突出。这项开创性研究表明，无意中的药物暴露已从环境媒体扩展到消费产品。
