Abstract：
OBJECTIVE: Aim: The aim of the research was to study the features of pancreatic exocrine insufficiency (EPI) in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM) at COVID-19.
METHODS: Materials and Methods: 72 patients with NAFLD and COVID-19 were examined. The patients have been divided into two groups: group 1 included 42 patients with NAFLD and insulin resistance (IR); group 2 consisted of 30 patients with NAFLD in the combination with type 2 DM. EPI was detected by 13С-mixed triglyceride breath test (13С-MTBT) in all the patients.
RESULTS: Results: The result of 13С-MTBT indicates EPI in the examined subjects of the 2 group. A significant decrease in the maximum concentration of 13СО2 between 150 and 210 min was also diagnosed in group 1 patients. research (up to 8.2 ± 0.9% - p < 0.05), however, the total concentration of 13СО2 at the end of 360 min. the study reached only 27.7 ± 1.1% (p < 0.05).
CONCLUSIONS: Conclusions: Based on the results of laboratory-instrumental methods of research, patients with NAFLD and type 2 diabetes with COVID-19 were diagnosed with severe EPI. The results of 13С-MTBT in NAFLD and IR with COVID-19 indicate a decrease in the functional reserves of the pancreas and the formation of its EPI.
METHODS: Materials and Methods: 72 patients with NAFLD and COVID-19 were examined. The patients have been divided into two groups: group 1 included 42 patients with NAFLD and insulin resistance (IR); group 2 consisted of 30 patients with NAFLD in the combination with type 2 DM. EPI was detected by 13С-mixed triglyceride breath test (13С-MTBT) in all the patients.
RESULTS: Results: The result of 13С-MTBT indicates EPI in the examined subjects of the 2 group. A significant decrease in the maximum concentration of 13СО2 between 150 and 210 min was also diagnosed in group 1 patients. research (up to 8.2 ± 0.9% - p < 0.05), however, the total concentration of 13СО2 at the end of 360 min. the study reached only 27.7 ± 1.1% (p < 0.05).
CONCLUSIONS: Conclusions: Based on the results of laboratory-instrumental methods of research, patients with NAFLD and type 2 diabetes with COVID-19 were diagnosed with severe EPI. The results of 13С-MTBT in NAFLD and IR with COVID-19 indicate a decrease in the functional reserves of the pancreas and the formation of its EPI.
摘要：
目的：目的：研究COVID-19患者非酒精性脂肪性肝病（NAFLD）和2型糖尿病（DM）患者胰腺外分泌功能不全（EPI）的特点。
方法：材料和方法：对72例NAFLD和COVID-19患者进行检查。将患者分为两组：第1组包括42例NAFLD和胰岛素抵抗（IR）患者；第2组包括30例NAFLD合并2型DM的患者。在所有患者中，通过13_混合甘油三酸酯呼气试验（13_MTBT）检测到EPI。
结果：结果：13_MTBT的结果表明2组受检对象中的EPI。在第1组患者中，还诊断出在150至210分钟之间的最大浓度显着降低。研究（高达8.2±0.9%-p<0.05），然而,360分钟结束时的总浓度为13‰2。该研究仅达到27.7±1.1％（p<0.05）。
结论：结论：根据实验室仪器研究方法的结果，合并COVID-19的NAFLD和2型糖尿病患者被诊断为严重EPI.NAFLD和COVID-19的IR中的13_MTBT结果表明胰腺的功能储备和EPI的形成减少。
方法：材料和方法：对72例NAFLD和COVID-19患者进行检查。将患者分为两组：第1组包括42例NAFLD和胰岛素抵抗（IR）患者；第2组包括30例NAFLD合并2型DM的患者。在所有患者中，通过13_混合甘油三酸酯呼气试验（13_MTBT）检测到EPI。
结果：结果：13_MTBT的结果表明2组受检对象中的EPI。在第1组患者中，还诊断出在150至210分钟之间的最大浓度显着降低。研究（高达8.2±0.9%-p<0.05），然而,360分钟结束时的总浓度为13‰2。该研究仅达到27.7±1.1％（p<0.05）。
结论：结论：根据实验室仪器研究方法的结果，合并COVID-19的NAFLD和2型糖尿病患者被诊断为严重EPI.NAFLD和COVID-19的IR中的13_MTBT结果表明胰腺的功能储备和EPI的形成减少。
