PDF(Pubmed)
Abstract：
Caesarean section scar diverticulum (CSD) is a significant cause of infertility among women who have previously had a Caesarean section, primarily due to persistent inflammatory exudation associated with this condition. Even though abnormal bacterial composition is identified as a critical factor leading to this chronic inflammation, clinical data suggest that a long-term cure is often unattainable with antibiotic treatment alone. In our study, we employed metagenomic analysis and mass spectrometry techniques to investigate the fungal composition in CSD and its interaction with bacteria. We discovered that local fungal abnormalities in CSD can disrupt the stability of the bacterial population and the entire microbial community by altering bacterial abundance via specific metabolites. For instance, Lachnellula suecica reduces the abundance of several Lactobacillus spp., such as Lactobacillus jensenii, by diminishing the production of metabolites like Goyaglycoside A and Janthitrem E. Concurrently, Clavispora lusitaniae and Ophiocordyceps australis can synergistically impact the abundance of Lactobacillus spp. by modulating metabolite abundance. Our findings underscore that abnormal fungal composition and activity are key drivers of local bacterial dysbiosis in CSD.
摘要：
剖腹产疤痕憩室（CSD）是先前进行过剖腹产的女性不孕的重要原因，主要是由于与这种情况相关的持续炎症渗出。尽管异常的细菌成分被认为是导致这种慢性炎症的关键因素，临床数据表明,单用抗生素治疗往往无法实现长期治愈.在我们的研究中,我们使用宏基因组分析和质谱技术来研究CSD中的真菌组成及其与细菌的相互作用。我们发现CSD中的局部真菌异常可以通过特定代谢物改变细菌丰度来破坏细菌种群和整个微生物群落的稳定性。例如,细细细乳减少了几种乳杆菌属的丰度。,比如Jensenii乳杆菌,通过减少像GoyaglycosideA和JanthitremE这样的代谢物的产生，lusitaniae和冬虫夏草可以协同影响乳杆菌属的丰度。通过调节代谢物丰度。我们的发现强调，异常的真菌组成和活性是CSD局部细菌菌群失调的关键驱动因素。
