PDF(Pubmed)
Abstract：
UNASSIGNED: Intravenous administration of azithromycin has been linked to severe hypotension in some case reports in the past. We report a further case of profound shock requiring excessive use of vasopressors and extracorporeal membrane oxygenation (ECMO).
UNASSIGNED: An 18-year-old Caucasian male was admitted due to fulminant myocarditis and signs of cardiogenic shock. He had to be put on venoarterial ECMO only hours after admission. Due to the occurrence of disseminated intravascular coagulation and heparin-induced thrombocytopenia, haemodynamic support was discontinued on Day 8. On Day 11 of his stay, the patient started to exhibit signs of severe infection and a single 1500 mg dose of azithromycin was prescribed. Immediately after starting the infusion, the patient developed profound hypotension and signs of cardiogenic shock. Consecutively, venoarterial ECMO had to be re-established, and the azithromycin infusion was stopped in the process. It took the restart of the compound to recognize the connection between the administration of the therapy and the occurrence of cardiogenic shock. After discontinuing azithromycin, no further sudden hypotensive episodes were recorded, and the patient received left ventricular assist device implantation as a bridge to recovery or transplant.
UNASSIGNED: Rapid-onset hypotension appears to be a very rare but important adverse drug reaction associated with intravenous administration of azithromycin. Factors such as preceding infection and reduced biventricular function may facilitate the described occurrence.
UNASSIGNED: An 18-year-old Caucasian male was admitted due to fulminant myocarditis and signs of cardiogenic shock. He had to be put on venoarterial ECMO only hours after admission. Due to the occurrence of disseminated intravascular coagulation and heparin-induced thrombocytopenia, haemodynamic support was discontinued on Day 8. On Day 11 of his stay, the patient started to exhibit signs of severe infection and a single 1500 mg dose of azithromycin was prescribed. Immediately after starting the infusion, the patient developed profound hypotension and signs of cardiogenic shock. Consecutively, venoarterial ECMO had to be re-established, and the azithromycin infusion was stopped in the process. It took the restart of the compound to recognize the connection between the administration of the therapy and the occurrence of cardiogenic shock. After discontinuing azithromycin, no further sudden hypotensive episodes were recorded, and the patient received left ventricular assist device implantation as a bridge to recovery or transplant.
UNASSIGNED: Rapid-onset hypotension appears to be a very rare but important adverse drug reaction associated with intravenous administration of azithromycin. Factors such as preceding infection and reduced biventricular function may facilitate the described occurrence.
摘要：
在过去的一些病例报告中，静脉给予阿奇霉素与严重低血压有关。我们报告了另一例严重休克，需要过度使用血管加压药和体外膜氧合（ECMO）。
■一名18岁白人男性因暴发性心肌炎和心源性休克征象入院。他必须在入院后仅几小时接受静脉动脉ECMO治疗。由于弥漫性血管内凝血和肝素诱导的血小板减少症的发生，血流动力学支持在第8天终止.在他逗留的第11天，患者开始出现严重感染的迹象,并开出单剂1500mg阿奇霉素.刚开始输液后,患者出现深度低血压和心源性休克迹象。连续,必须重新建立静脉动脉ECMO，在此过程中停止了阿奇霉素的输注。重新启动该化合物以认识到治疗的给药与心源性休克的发生之间的联系。停用阿奇霉素后，没有记录到更多的突然低血压发作,患者接受左心室辅助装置植入作为康复或移植的桥梁。
■快速发作性低血压似乎是一种非常罕见但重要的药物不良反应，与静脉注射阿奇霉素有关。先前感染和双心室功能降低等因素可能会促进所述的发生。
■一名18岁白人男性因暴发性心肌炎和心源性休克征象入院。他必须在入院后仅几小时接受静脉动脉ECMO治疗。由于弥漫性血管内凝血和肝素诱导的血小板减少症的发生，血流动力学支持在第8天终止.在他逗留的第11天，患者开始出现严重感染的迹象,并开出单剂1500mg阿奇霉素.刚开始输液后,患者出现深度低血压和心源性休克迹象。连续,必须重新建立静脉动脉ECMO，在此过程中停止了阿奇霉素的输注。重新启动该化合物以认识到治疗的给药与心源性休克的发生之间的联系。停用阿奇霉素后，没有记录到更多的突然低血压发作,患者接受左心室辅助装置植入作为康复或移植的桥梁。
■快速发作性低血压似乎是一种非常罕见但重要的药物不良反应，与静脉注射阿奇霉素有关。先前感染和双心室功能降低等因素可能会促进所述的发生。
