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Abstract：
Wound repair is a complex challenge for both clinical practitioners and researchers. Conventional approaches for wound repair have several limitations. Stem cell-based therapy has emerged as a novel strategy to address this issue, exhibiting significant potential for enhancing wound healing rates, improving wound quality, and promoting skin regeneration. However, the use of stem cells in skin regeneration presents several challenges. Recently, stem cells and biomaterials have been identified as crucial components of the wound-healing process. Combination therapy involving the development of biocompatible scaffolds, accompanying cells, multiple biological factors, and structures resembling the natural extracellular matrix (ECM) has gained considerable attention. Biological scaffolds encompass a range of biomaterials that serve as platforms for seeding stem cells, providing them with an environment conducive to growth, similar to that of the ECM. These scaffolds facilitate the delivery and application of stem cells for tissue regeneration and wound healing. This article provides a comprehensive review of the current developments and applications of biological scaffolds for stem cells in wound healing, emphasizing their capacity to facilitate stem cell adhesion, proliferation, differentiation, and paracrine functions. Additionally, we identify the pivotal characteristics of the scaffolds that contribute to enhanced cellular activity.
摘要：
伤口修复对于临床从业者和研究人员来说都是一个复杂的挑战。用于伤口修复的常规方法具有若干局限性。基于干细胞的治疗已经成为解决这个问题的一种新策略。表现出显著的提高伤口愈合率的潜力，改善伤口质量，促进皮肤再生。然而,在皮肤再生中使用干细胞提出了一些挑战。最近,干细胞和生物材料已被确定为伤口愈合过程的关键组成部分。涉及生物相容性支架开发的联合治疗，伴随细胞,多种生物学因素，和类似于天然细胞外基质(ECM)的结构已获得相当多的关注。生物支架包括一系列生物材料，用作接种干细胞的平台，为他们提供有利于成长的环境，类似于ECM。这些支架促进干细胞的递送和应用,用于组织再生和伤口愈合。本文就目前干细胞生物支架在创面愈合中的研究进展及应用作一综述。强调它们促进干细胞粘附的能力，扩散,分化,和旁分泌功能。此外,我们确定了有助于增强细胞活性的支架的关键特征。
