PDF(Pubmed)
Abstract：
Craniofacial reconstruction faces many challenges, including high complexity, strong specificity, severe injury, irregular and complex wounds, and high risk of bleeding. Traditionally, the \"gold standard\" for treating craniofacial bone defects has been tissue transplantation, which involves the transplantation of bone, cartilage, skin, and other tissues from other parts of the body. However, the shape of craniofacial bone and cartilage structures varies greatly and is distinctly different from ordinary long bones. Craniofacial bones originate from the neural crest, while long bones originate from the mesoderm. These factors contribute to the poor effectiveness of tissue transplantation in repairing craniofacial defects. Autologous mesenchymal stem cell transplantation exhibits excellent pluripotency, low immunogenicity, and minimally invasive properties, and is considered a potential alternative to tissue transplantation for treating craniofacial defects. Researchers have found that both craniofacial-specific mesenchymal stem cells and mesenchymal stem cells from other parts of the body have significant effects on the restoration and reconstruction of craniofacial bones, cartilage, wounds, and adipose tissue. In addition, the continuous development and application of tissue engineering technology provide new ideas for craniofacial repair. With the continuous exploration of mesenchymal stem cells by researchers and the continuous development of tissue engineering technology, the use of autologous mesenchymal stem cell transplantation for craniofacial reconstruction has gradually been accepted and promoted. This article will review the applications of various types of mesenchymal stem cells and related tissue engineering in craniofacial repair and reconstruction.
摘要：
颅面重建面临许多挑战,包括高复杂性，特异性强，重伤,不规则和复杂的伤口，出血风险高.传统上,治疗颅面骨缺损的“金标准”一直是组织移植，涉及骨移植，软骨，皮肤,以及身体其他部位的其他组织。然而,颅面骨和软骨结构的形状差异很大，与普通的长骨明显不同。颅面骨骼起源于神经c，而长骨起源于中胚层。这些因素导致组织移植修复颅面缺损的效果不佳。自体间充质干细胞移植表现出优异的多能性,低免疫原性,和微创特性，并且被认为是治疗颅面缺损的组织移植的潜在替代方法。研究人员发现,无论是颅面特异性间充质干细胞,还是身体其他部位的间充质干细胞,都对颅面骨骼的修复重建有显著的作用,软骨，伤口,和脂肪组织。此外,组织工程技术的不断发展和应用为颅面修复提供了新思路。随着研究人员对间充质干细胞的不断探索和组织工程技术的不断发展,自体间充质干细胞移植用于颅面重建逐渐被接受和推广。本文就各类间充质干细胞及其相关组织工程在颅面修复重建中的应用作一综述。
