PDF(Pubmed)
Abstract：
Neuro bone tissue engineering is a multidisciplinary field that combines both principles of neurobiology and bone tissue engineering to develop innovative strategies for repairing and regenerating injured bone tissues. Despite the fact that regeneration and development are considered two distinct biological processes, yet regeneration can be considered the reactivation of development in later life stages to restore missing tissues. It is noteworthy that the regeneration capabilities are distinct and vary from one organism to another (teleost fishes, hydra, humans), or even in the same organism can vary dependent on the injured tissue itself (Human central nervous system vs. peripheral nervous system). The skeletal tissue is highly innervated, peripheral nervous system plays a role in conveying the signals and connecting the central nervous system with the peripheral organs, moreover it has been shown that they play an important role in tissue regeneration. Their regeneration role is conveyed by the different cells\' resident in it and in its endoneurium (fibroblasts, microphages, vasculature associated cells, and Schwann cells) these cells secrete various growth factors (NGF, BDNF, GDNF, NT-3, and bFGF) that contribute to the regenerative phenotype. The peripheral nervous system and central nervous system synchronize together in regulating bone homeostasis and regeneration through neurogenic factors and neural circuits. Receptors of important central nervous system peptides such as Serotonin, Leptin, Semaphorins, and BDNF are expressed in bone tissue playing a role in bone homeostasis, metabolism and regeneration. This review will highlight the crosstalk between peripheral nerves and bone in the developmental stages as well as in regeneration and different neuro-bone tissue engineering strategies for repairing severe bone injuries.
摘要：
神经骨组织工程是一个多学科领域，结合了神经生物学和骨组织工程的原理，以开发修复和再生受损骨组织的创新策略。尽管再生和发育被认为是两个不同的生物过程，然而，再生可以被认为是在生命后期重新激活发育，以恢复缺失的组织。值得注意的是，再生能力是不同的，并且从一个有机体到另一个有机体(硬骨鱼，九头蛇,人类)，甚至在同一生物体中也可以根据受伤组织本身而变化(人类中枢神经系统与周围神经系统）。骨骼组织受到高度神经支配，外周神经系统在传递信号和连接中枢神经系统与外周器官中起着重要作用，此外，已经表明它们在组织再生中起着重要作用。它们的再生作用由驻留在其及其神经内膜中的不同细胞（成纤维细胞，微噬菌体,血管相关细胞，和雪旺氏细胞）这些细胞分泌各种生长因子（NGF，BDNF,GDNF,NT-3和bFGF）有助于再生表型。周围神经系统和中枢神经系统通过神经源性因子和神经回路在调节骨稳态和再生方面同步。重要的中枢神经系统肽的受体，如5-羟色胺，瘦素,信号素,BDNF在骨组织中表达，在骨稳态中起作用，新陈代谢和再生。这篇综述将重点介绍发育阶段周围神经与骨骼之间的串扰以及再生和修复严重骨骼损伤的不同神经骨组织工程策略。
